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- W2023792679 abstract "An equation has been derived which describes the short time behaviour of the release of a dispersed drug from a homogeneous matrix of general shape using the pseudo-steady-state approximation of Higuchi. The equation has been used successfully to describe the experimentally observed release in vitro of Sulphamethizole from poly(hydroxybutyrate) or poly(hydroxybutyrate)/poly(hydroxyvalerate) microparticles of irregular shape for up to 5–8 h of dissolution time corresponding to between 40–70% drug release. The equation is only valid for systems where erosion or swelling of the matrix does not contribute to drug release during the short time period." @default.
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- W2023792679 date "1987-06-01" @default.
- W2023792679 modified "2023-10-16" @default.
- W2023792679 title "Application of the Higuchi model for drug release from dispersed matrices to particles of general shape" @default.
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- W2023792679 doi "https://doi.org/10.1016/0378-5173(87)90008-1" @default.
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