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- W2023794887 abstract "Autotransfusion from controlled hemorrhage into a pelvic extraperitoneal pocket was performed in 19 baboons using a commercial autotransfusion apparatus. Nine heparinized animals (H) were compared to ten in which extracorporeal citrate plus cell-washing (CW) was employed. Serum hemoglobin levels were elevated in the H group but not in the CW group during autotransfusion. Elevated PT and PTT developed in both groups during autotransfusion with return to normal at 24 hr. Serum fibrinogen levels remained normal in the H group but were depressed in the CW group. Fibrin split products were more elevated in the H group than in the CW group. Interestingly, in the CW group total proteins were depressed with a disproportionate loss in the non-albumin fraction. The groups never differed from each other with respect to hematocrit, platelet aggregability, and serum total hemolytic complement levels. Both techniques provided adequate hypocoagulability for autotransfusion. The elevated PT, PTT, fibrin split products (FSP) and decreased fibrinogen represent a clear picture of disseminated intravascular coagulopathy in the H group. The lesser changes in the CW group suggest that the combination of citrate plus plasmaphoresis kept any intravascular coagulopathy at a more tolerable level in the CW group. The lower plasma hemoglobin levels in the CW group decreased the threat to renal function in the presence of marked hemolysis. These findings suggest that extracorporeal citrate plus cell-washing is an attractive alternative to heparinization of patients for autotransfusion." @default.
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- W2023794887 date "1976-04-01" @default.
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- W2023794887 title "Heparin versus citrate anticoagulation in autotransfusion" @default.
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- W2023794887 doi "https://doi.org/10.1016/0022-4804(76)90022-6" @default.
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