FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023797842> ?p ?o ?g. }

• W2023797842 endingPage "1536" @default.
• W2023797842 startingPage "1524" @default.
• W2023797842 abstract "The P-glycoprotein (Pgp), a drug efflux pump, is expressed in intestinal epithelial cells, where it constitutes a barrier against xenobiotics. In inflammatory bowel disease, a dysregulation in the production of tumor necrosis factor (TNF)alpha and interferon (IFN)gamma, and an alteration of Pgp expression and activity have been reported. The aim of this study was to investigate the effects of TNF alpha and IFN gamma on intestinal Pgp expression, activity, and localization in Caco-2 cells grown on filters. TNF alpha induced both a strong time-dependent diminution (-56%) of MDR1 mRNA (semiquantitative reverse transcription polymerase chain reaction) and a significant decrease of unidirectional transport of rhodamine 123 after 48 h of exposure at 10 ng/mL. By confocal laser scanning microscopy, the Pgp was mainly localized to the apical plasma membrane of both control and TNF alpha-treated cells. By contrast, IFN gamma induced up-regulation of both mRNA MDR1 and Pgp protein expression without incidence on Pgp activity. Interestingly, a colocalization of Pgp with lateral F-actin was observed. Associated with TNF alpha, IFN gamma produced neither an antagonist nor synergistic effect on Pgp activity. In conclusion, our results demonstrate an inhibitory effect of TNF alpha and no effect of IFN gamma on Pgp transport activity using rhodamine 123 as a substrate. Mechanisms of action of these cytokines remain to be studied." @default.
• W2023797842 created "2016-06-24" @default.
• W2023797842 creator A5028335825 @default.
• W2023797842 creator A5036003981 @default.
• W2023797842 creator A5071030872 @default.
• W2023797842 creator A5073921102 @default.
• W2023797842 date "2004-06-01" @default.
• W2023797842 modified "2023-10-08" @default.
• W2023797842 title "Effect of tumor necrosis factor‐α and interferon‐γ on intestinal P‐glycoprotein expression, activity, and localization in Caco‐2 cells" @default.
• W2023797842 cites W115287656 @default.
• W2023797842 cites W1570674543 @default.
• W2023797842 cites W1730863938 @default.
• W2023797842 cites W1989210966 @default.
• W2023797842 cites W1989386799 @default.
• W2023797842 cites W2000795956 @default.
• W2023797842 cites W2004434518 @default.
• W2023797842 cites W2009980852 @default.
• W2023797842 cites W2014588425 @default.
• W2023797842 cites W2043835982 @default.
• W2023797842 cites W2046189325 @default.
• W2023797842 cites W2053491542 @default.
• W2023797842 cites W2055645153 @default.
• W2023797842 cites W2057626594 @default.
• W2023797842 cites W2058394127 @default.
• W2023797842 cites W2062699557 @default.
• W2023797842 cites W2064087173 @default.
• W2023797842 cites W2066372209 @default.
• W2023797842 cites W2068537822 @default.
• W2023797842 cites W2075183125 @default.
• W2023797842 cites W2084534912 @default.
• W2023797842 cites W2085699130 @default.
• W2023797842 cites W2092839327 @default.
• W2023797842 cites W2105390714 @default.
• W2023797842 cites W2110174748 @default.
• W2023797842 cites W2146557349 @default.
• W2023797842 cites W2150231804 @default.
• W2023797842 cites W2150699672 @default.
• W2023797842 cites W2177396386 @default.
• W2023797842 cites W2189616626 @default.
• W2023797842 cites W4251751811 @default.
• W2023797842 cites W97686115 @default.
• W2023797842 doi "https://doi.org/10.1002/jps.20072" @default.
• W2023797842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15124210" @default.
• W2023797842 hasPublicationYear "2004" @default.
• W2023797842 type Work @default.
• W2023797842 sameAs 2023797842 @default.
• W2023797842 citedByCount "67" @default.
• W2023797842 countsByYear W20237978422012 @default.
• W2023797842 countsByYear W20237978422013 @default.
• W2023797842 countsByYear W20237978422014 @default.
• W2023797842 countsByYear W20237978422015 @default.
• W2023797842 countsByYear W20237978422016 @default.
• W2023797842 countsByYear W20237978422017 @default.
• W2023797842 countsByYear W20237978422018 @default.
• W2023797842 countsByYear W20237978422019 @default.
• W2023797842 countsByYear W20237978422020 @default.
• W2023797842 countsByYear W20237978422021 @default.
• W2023797842 countsByYear W20237978422022 @default.
• W2023797842 countsByYear W20237978422023 @default.
• W2023797842 crossrefType "journal-article" @default.
• W2023797842 hasAuthorship W2023797842A5028335825 @default.
• W2023797842 hasAuthorship W2023797842A5036003981 @default.
• W2023797842 hasAuthorship W2023797842A5071030872 @default.
• W2023797842 hasAuthorship W2023797842A5073921102 @default.
• W2023797842 hasConcept C133936738 @default.
• W2023797842 hasConcept C134018914 @default.
• W2023797842 hasConcept C153911025 @default.
• W2023797842 hasConcept C17991360 @default.
• W2023797842 hasConcept C185592680 @default.
• W2023797842 hasConcept C200082930 @default.
• W2023797842 hasConcept C203014093 @default.
• W2023797842 hasConcept C2778589691 @default.
• W2023797842 hasConcept C2778690821 @default.
• W2023797842 hasConcept C2778707650 @default.
• W2023797842 hasConcept C2778754761 @default.
• W2023797842 hasConcept C2780841837 @default.
• W2023797842 hasConcept C40209533 @default.
• W2023797842 hasConcept C501593827 @default.
• W2023797842 hasConcept C55493867 @default.
• W2023797842 hasConcept C86803240 @default.
• W2023797842 hasConceptScore W2023797842C133936738 @default.
• W2023797842 hasConceptScore W2023797842C134018914 @default.
• W2023797842 hasConceptScore W2023797842C153911025 @default.
• W2023797842 hasConceptScore W2023797842C17991360 @default.
• W2023797842 hasConceptScore W2023797842C185592680 @default.
• W2023797842 hasConceptScore W2023797842C200082930 @default.
• W2023797842 hasConceptScore W2023797842C203014093 @default.
• W2023797842 hasConceptScore W2023797842C2778589691 @default.
• W2023797842 hasConceptScore W2023797842C2778690821 @default.
• W2023797842 hasConceptScore W2023797842C2778707650 @default.
• W2023797842 hasConceptScore W2023797842C2778754761 @default.
• W2023797842 hasConceptScore W2023797842C2780841837 @default.
• W2023797842 hasConceptScore W2023797842C40209533 @default.
• W2023797842 hasConceptScore W2023797842C501593827 @default.
• W2023797842 hasConceptScore W2023797842C55493867 @default.
• W2023797842 hasConceptScore W2023797842C86803240 @default.
• W2023797842 hasIssue "6" @default.
• W2023797842 hasLocation W20237978421 @default.

• next