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• W2023798912 abstract "Many icosahedral viruses undergo large-scale conformational transitions between icosahedrally symmetric conformations during their life cycles. However, whether icosahedral symmetry is maintained along the transition pathways for this process is unknown. By employing a simplified and directed structure-based potential we compute an ensemble of transition pathways for the maturation transition of bacteriophage HK97. We observe localized symmetry-breaking events, but find that the large-scale displacements are dominated by icosahedrally symmetric deformation modes. We find that all pathways obey a common mechanism characterized by formation of pentameric contacts early in the transition." @default.
• W2023798912 created "2016-06-24" @default.
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• W2023798912 date "2012-02-01" @default.
• W2023798912 modified "2023-10-10" @default.
• W2023798912 title "Exploring the Symmetry and Mechanism of Virus Capsid Maturation Via an Ensemble of Pathways" @default.
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• W2023798912 doi "https://doi.org/10.1016/j.bpj.2011.12.016" @default.
• W2023798912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3274788" @default.
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