FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023803166> ?p ?o ?g. }

• W2023803166 endingPage "503" @default.
• W2023803166 startingPage "492" @default.
• W2023803166 abstract "Noscapine crosses blood–brain-barrier and inhibits proliferation of glioblastoma cells. However, short plasma half-life and rapid elimination necessitate the administration of multiple injections for successive chemotherapy. Noscapine bearing solid lipid nanoparticles, Nos-SLN and poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine, Nos-PEG-SLN of 61.3 ± 9.3-nm and 80.5 ± 8.9-nm containing 80.4 ± 3.2% and 83.6 ± 1.2% of Nos, were constructed. First order kinetic and Higuchi equation were followed to release the Nos at intracellular pH ~ 4.5. Further, a decrease in IC50 (Nos; 40.5 μM > Nos-SLN; 27.2 μM > 20.8 μM) and enhanced subG1 population were observed in U87cells. Plasma half-life was enhanced up to ~ 11-fold and ~ 5-fold by Nos-PEG-SLN and Nos-SLN which significantly (P < 0.05) deposits 400.7 μg/g and 313.1 μg/g of Nos in comparison to 233.2 μg/g by drug solution. This is first report demonstrating a workable approach to regulate the administration of multiple injections of Nos, warranting further in vivo tumor regression study for superior management of brain cancer. This report describes a possible approach to regulate the administration of multiple injections of Noscapine using solid lipid nanoparticles. The data warrant further in vivo tumor regression studies for optimal management of glioblastoma, a generally very poorly treatable brain cancer." @default.
• W2023803166 created "2016-06-24" @default.
• W2023803166 creator A5034070547 @default.
• W2023803166 creator A5035479926 @default.
• W2023803166 creator A5047025432 @default.
• W2023803166 creator A5054927028 @default.
• W2023803166 creator A5060259320 @default.
• W2023803166 creator A5076147458 @default.
• W2023803166 date "2013-05-01" @default.
• W2023803166 modified "2023-10-02" @default.
• W2023803166 title "Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells" @default.
• W2023803166 cites W110939414 @default.
• W2023803166 cites W1482904772 @default.
• W2023803166 cites W1964026121 @default.
• W2023803166 cites W1966365319 @default.
• W2023803166 cites W1969940625 @default.
• W2023803166 cites W1970447790 @default.
• W2023803166 cites W1970850132 @default.
• W2023803166 cites W1983090757 @default.
• W2023803166 cites W1987342867 @default.
• W2023803166 cites W2000177666 @default.
• W2023803166 cites W2017916544 @default.
• W2023803166 cites W2018504340 @default.
• W2023803166 cites W2020882358 @default.
• W2023803166 cites W2023062773 @default.
• W2023803166 cites W2026575542 @default.
• W2023803166 cites W2063672140 @default.
• W2023803166 cites W2086319321 @default.
• W2023803166 cites W2086618179 @default.
• W2023803166 cites W2114918609 @default.
• W2023803166 cites W2136082930 @default.
• W2023803166 cites W2146408988 @default.
• W2023803166 cites W2154262521 @default.
• W2023803166 cites W2155197175 @default.
• W2023803166 cites W2159832141 @default.
• W2023803166 cites W2166279159 @default.
• W2023803166 cites W2314444875 @default.
• W2023803166 cites W2326486821 @default.
• W2023803166 doi "https://doi.org/10.1016/j.nano.2012.10.003" @default.
• W2023803166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23117045" @default.
• W2023803166 hasPublicationYear "2013" @default.
• W2023803166 type Work @default.
• W2023803166 sameAs 2023803166 @default.
• W2023803166 citedByCount "110" @default.
• W2023803166 countsByYear W20238031662013 @default.
• W2023803166 countsByYear W20238031662014 @default.
• W2023803166 countsByYear W20238031662015 @default.
• W2023803166 countsByYear W20238031662016 @default.
• W2023803166 countsByYear W20238031662017 @default.
• W2023803166 countsByYear W20238031662018 @default.
• W2023803166 countsByYear W20238031662019 @default.
• W2023803166 countsByYear W20238031662020 @default.
• W2023803166 countsByYear W20238031662021 @default.
• W2023803166 countsByYear W20238031662022 @default.
• W2023803166 countsByYear W20238031662023 @default.
• W2023803166 crossrefType "journal-article" @default.
• W2023803166 hasAuthorship W2023803166A5034070547 @default.
• W2023803166 hasAuthorship W2023803166A5035479926 @default.
• W2023803166 hasAuthorship W2023803166A5047025432 @default.
• W2023803166 hasAuthorship W2023803166A5054927028 @default.
• W2023803166 hasAuthorship W2023803166A5060259320 @default.
• W2023803166 hasAuthorship W2023803166A5076147458 @default.
• W2023803166 hasConcept C112705442 @default.
• W2023803166 hasConcept C150903083 @default.
• W2023803166 hasConcept C178790620 @default.
• W2023803166 hasConcept C185592680 @default.
• W2023803166 hasConcept C199529486 @default.
• W2023803166 hasConcept C202751555 @default.
• W2023803166 hasConcept C207001950 @default.
• W2023803166 hasConcept C2777516009 @default.
• W2023803166 hasConcept C2777667214 @default.
• W2023803166 hasConcept C2777752497 @default.
• W2023803166 hasConcept C2779200813 @default.
• W2023803166 hasConcept C2780035454 @default.
• W2023803166 hasConcept C2908647359 @default.
• W2023803166 hasConcept C55493867 @default.
• W2023803166 hasConcept C71240020 @default.
• W2023803166 hasConcept C71924100 @default.
• W2023803166 hasConcept C86803240 @default.
• W2023803166 hasConcept C98274493 @default.
• W2023803166 hasConcept C99454951 @default.
• W2023803166 hasConceptScore W2023803166C112705442 @default.
• W2023803166 hasConceptScore W2023803166C150903083 @default.
• W2023803166 hasConceptScore W2023803166C178790620 @default.
• W2023803166 hasConceptScore W2023803166C185592680 @default.
• W2023803166 hasConceptScore W2023803166C199529486 @default.
• W2023803166 hasConceptScore W2023803166C202751555 @default.
• W2023803166 hasConceptScore W2023803166C207001950 @default.
• W2023803166 hasConceptScore W2023803166C2777516009 @default.
• W2023803166 hasConceptScore W2023803166C2777667214 @default.
• W2023803166 hasConceptScore W2023803166C2777752497 @default.
• W2023803166 hasConceptScore W2023803166C2779200813 @default.
• W2023803166 hasConceptScore W2023803166C2780035454 @default.
• W2023803166 hasConceptScore W2023803166C2908647359 @default.
• W2023803166 hasConceptScore W2023803166C55493867 @default.
• W2023803166 hasConceptScore W2023803166C71240020 @default.
• W2023803166 hasConceptScore W2023803166C71924100 @default.
• W2023803166 hasConceptScore W2023803166C86803240 @default.

• next