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- W2023807785 abstract "Previously, two B (B1 and B2)- and four T (T1, T2, T3, T4)-lymphocyte subpopulations have been identified in human blood smears by bacterial adherence. Here, to study the functional differences between these subpopulations the T1T2 cells were separated from T3T4 cells by selective adherence to Escherichia coli-24 monolayers. The adherent cells (T1T2 cells) responded well to concanavalin A in 3-day cultures and in mixed lymphocyte culture (MLC) in 6-day cultures and developed into cells specifically cytotoxic for allogeneic lymphocytes. The nonadherent cells (T3T4 cells) cultured for the same length of time were poorly responsive to concanavalin A, variably responsive in MLC, and poorly active in specific cytotoxicity. The T3T4 cells were naturally cytotoxic for allogeneic lymphocytes and for a normal lymphoblastoid cell line. We concluded that the T cells that bind E. coli-2 (T1T2 cells) are functionally different from those that do not bind (T3T4 cells)." @default.
- W2023807785 created "2016-06-24" @default.
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- W2023807785 date "1979-11-01" @default.
- W2023807785 modified "2023-09-27" @default.
- W2023807785 title "Human lymphocyte subpopulations identified by bacterial adherence are functionally different" @default.
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- W2023807785 doi "https://doi.org/10.1016/0008-8749(79)90097-2" @default.
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