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- W2023807907 abstract "The ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) may provide modulatory signals that, respectively, influence hippocampal (HPC)- and striatal-dependent memory. Electrophysiological studies investigating neural correlates of learning and memory of dopamine (DA) neurons during classical conditioning tasks have found DA neural activity in VTA and SNc to be tightly coupled with reinforcement expectations. Also, VTA integrity and DA in HPC have been found to regulate the encoding of HPC-dependent memories. Therefore, to determine the nature of the neural code HPC may receive from midbrain DA regions, the present study investigated VTA and SNc neural activity as navigating rats engaged in new spatial learning and experienced changes in expected goal locations. VTA and SNc cells were differentially engaged during training to a series of three novel goal locations. During task acquisition, the peak firing rates of VTA neurons decreased at the time of reward and shifted to time points before reward retrieval, whereas the peak firing rates of SNc neurons remained elevated at the time of reward during training to all three goal locations. Both VTA and SNc egocentric coding was strongest during training to the first goal location, which coincided with the time subjects learned the behavioral rules specific to the task. These data imply that VTA and SNc play complementary yet distinct roles in spatial learning to optimize adaptive behavior." @default.
- W2023807907 created "2016-06-24" @default.
- W2023807907 creator A5012795230 @default.
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- W2023807907 date "2011-03-29" @default.
- W2023807907 modified "2023-09-23" @default.
- W2023807907 title "Ventral tegmental area and substantia nigra neural correlates of spatial learning" @default.
- W2023807907 cites W1965671642 @default.
- W2023807907 cites W1973229581 @default.
- W2023807907 cites W1975705681 @default.
- W2023807907 cites W1976442866 @default.
- W2023807907 cites W1977490836 @default.
- W2023807907 cites W1980571433 @default.
- W2023807907 cites W1982522522 @default.
- W2023807907 cites W1982771150 @default.
- W2023807907 cites W1983398462 @default.
- W2023807907 cites W1983985508 @default.
- W2023807907 cites W1984315717 @default.
- W2023807907 cites W1990680291 @default.
- W2023807907 cites W1992431665 @default.
- W2023807907 cites W1993271745 @default.
- W2023807907 cites W1994984635 @default.
- W2023807907 cites W2001729320 @default.
- W2023807907 cites W2007203345 @default.
- W2023807907 cites W2010554387 @default.
- W2023807907 cites W2012848446 @default.
- W2023807907 cites W2015043513 @default.
- W2023807907 cites W2015200492 @default.
- W2023807907 cites W2016186456 @default.
- W2023807907 cites W2016985810 @default.
- W2023807907 cites W2019982479 @default.
- W2023807907 cites W2020969390 @default.
- W2023807907 cites W2026112465 @default.
- W2023807907 cites W2031336666 @default.
- W2023807907 cites W2042057828 @default.
- W2023807907 cites W2042436410 @default.
- W2023807907 cites W2043896273 @default.
- W2023807907 cites W2051895234 @default.
- W2023807907 cites W2052515926 @default.
- W2023807907 cites W2055225131 @default.
- W2023807907 cites W2055690979 @default.
- W2023807907 cites W2059702479 @default.
- W2023807907 cites W2066868744 @default.
- W2023807907 cites W2067147530 @default.
- W2023807907 cites W2073846731 @default.
- W2023807907 cites W2087712889 @default.
- W2023807907 cites W2088445784 @default.
- W2023807907 cites W2093024075 @default.
- W2023807907 cites W2093307165 @default.
- W2023807907 cites W2095088925 @default.
- W2023807907 cites W2098342476 @default.
- W2023807907 cites W2107525024 @default.
- W2023807907 cites W2107614799 @default.
- W2023807907 cites W2109059823 @default.
- W2023807907 cites W2110432917 @default.
- W2023807907 cites W2113895006 @default.
- W2023807907 cites W2114586089 @default.
- W2023807907 cites W2117726420 @default.
- W2023807907 cites W2120066727 @default.
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- W2023807907 cites W2123022860 @default.
- W2023807907 cites W2126680030 @default.
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- W2023807907 cites W2150299732 @default.
- W2023807907 cites W2155569983 @default.
- W2023807907 cites W2162579782 @default.
- W2023807907 cites W2168163387 @default.
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- W2023807907 doi "https://doi.org/10.1101/lm.1895211" @default.
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