Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023808179> ?p ?o ?g. }
- W2023808179 abstract "Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10−13) and corneal curvature (Pmeta=2.9 × 10−40) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case–control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta=1.13, Pmeta=0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia. Myopia is a significant and increasing public health concern. Here Miyake et al. conduct a genome-wide association study and identify WNT7Bas a susceptibility gene across different ethnic groups, suggesting a possible role in the development of myopia." @default.
- W2023808179 created "2016-06-24" @default.
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- W2023808179 date "2015-03-31" @default.
- W2023808179 modified "2023-10-18" @default.
- W2023808179 title "Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia" @default.
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