FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023808685> ?p ?o ?g. }

• W2023808685 endingPage "1537" @default.
• W2023808685 startingPage "1529" @default.
• W2023808685 abstract "A significant proportion of 131IUDR-labelled cells from murine leukemia cell lines L1210 and P388, but not the L5178Y lymphoma cell line, are retained in the bone marrow (B.M.) following i.v. injection into syngeneic mice. Following this, L1210 and P388 cells grow and rapidly replace the normal hematopoietic cells of the B.M. L1210 and P388 cells, but not several lymphoma cell lines, also bind avidly to monolayers of B.M. stromal cells (Dexter cultures) and soon overgrow the cultures following rapid cell proliferation. P388 cells bound equally well to confluent monolayers of B.M., whole mouse embryo and newborn mouse kidney while L1210 cells bound well to B.M. and whole mouse embryo but showed little binding to newborn kidney monolayers. The accumulation of the two leukemia cell lines in the B.M. was constant and indistinguishable over a 48-h period. In contrast, in both spleen and liver the number of L1210 cells decreased during the same period while P388 cells were retained at a constant level. Generally there was a lack of correlation of B.M. metastasis of a cell line and its metastasis to other organs although P388 cells, but not L1210 cells, demonstrated a tremendous capacity for metastatic growth in both spleen and liver. Normal B.M. cells were fused with the syngeneic SP2/0 murine myeloma fusor line and 10 hybridomas plus the SP2/0 parent were tested for in-vitro adherence to B.M. monolayers and in-vivo metastatic behavior. The same 3 (out of 10) hybridomas showed a high level of adherence to B.M. monolayers, high levels of retention of cells in the B.M. following i.v. injection, and rapid growth and takeover of the normal B.M. In marked contrast, neither the SP2/0 parent nor the remaining 7 hybridomas show significant adherence, B.M. retention or growth in the B.M. A distinct lack of correlation of B.M. vs liver or spleen metastasis was once again noted for the hybridomas although all of the hybridomas showed much less metastatic growth in the liver than the SP2/0 parent. Seven out of 10 hybridomas also showed less metastatic growth in the spleen including all 3 of the hybridomas which showed preferential growth in the B.M. Our data are consistent with the existence of cell surface ‘homing’ receptors on leukemia cells for normal B.M. stromal cells which function to retain the leukemia cells in the B.M. Such receptors might serve as functional markers for cell differentiation and leukemia classification." @default.
• W2023808685 created "2016-06-24" @default.
• W2023808685 creator A5012922458 @default.
• W2023808685 creator A5068567314 @default.
• W2023808685 date "1985-01-01" @default.
• W2023808685 modified "2023-09-25" @default.
• W2023808685 title "Further evidence for the existence of ‘homing’ receptors on murine leukemia cells which mediate adherence to normal bone marrow stromal cells" @default.
• W2023808685 cites W1606491117 @default.
• W2023808685 cites W1618054703 @default.
• W2023808685 cites W2019693845 @default.
• W2023808685 cites W2058694296 @default.
• W2023808685 cites W2061140050 @default.
• W2023808685 cites W2065869254 @default.
• W2023808685 cites W2117713457 @default.
• W2023808685 cites W2409902848 @default.
• W2023808685 cites W956068982 @default.
• W2023808685 doi "https://doi.org/10.1016/0145-2126(85)90046-3" @default.
• W2023808685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3001437" @default.
• W2023808685 hasPublicationYear "1985" @default.
• W2023808685 type Work @default.
• W2023808685 sameAs 2023808685 @default.
• W2023808685 citedByCount "18" @default.
• W2023808685 crossrefType "journal-article" @default.
• W2023808685 hasAuthorship W2023808685A5012922458 @default.
• W2023808685 hasAuthorship W2023808685A5068567314 @default.
• W2023808685 hasConcept C109159458 @default.
• W2023808685 hasConcept C109316439 @default.
• W2023808685 hasConcept C150903083 @default.
• W2023808685 hasConcept C151872237 @default.
• W2023808685 hasConcept C153911025 @default.
• W2023808685 hasConcept C159654299 @default.
• W2023808685 hasConcept C16930146 @default.
• W2023808685 hasConcept C18903297 @default.
• W2023808685 hasConcept C202751555 @default.
• W2023808685 hasConcept C203014093 @default.
• W2023808685 hasConcept C207001950 @default.
• W2023808685 hasConcept C2778453870 @default.
• W2023808685 hasConcept C2778461978 @default.
• W2023808685 hasConcept C2780007613 @default.
• W2023808685 hasConcept C2780017796 @default.
• W2023808685 hasConcept C2780931953 @default.
• W2023808685 hasConcept C28328180 @default.
• W2023808685 hasConcept C502942594 @default.
• W2023808685 hasConcept C54355233 @default.
• W2023808685 hasConcept C55493867 @default.
• W2023808685 hasConcept C81885089 @default.
• W2023808685 hasConcept C86803240 @default.
• W2023808685 hasConcept C95444343 @default.
• W2023808685 hasConceptScore W2023808685C109159458 @default.
• W2023808685 hasConceptScore W2023808685C109316439 @default.
• W2023808685 hasConceptScore W2023808685C150903083 @default.
• W2023808685 hasConceptScore W2023808685C151872237 @default.
• W2023808685 hasConceptScore W2023808685C153911025 @default.
• W2023808685 hasConceptScore W2023808685C159654299 @default.
• W2023808685 hasConceptScore W2023808685C16930146 @default.
• W2023808685 hasConceptScore W2023808685C18903297 @default.
• W2023808685 hasConceptScore W2023808685C202751555 @default.
• W2023808685 hasConceptScore W2023808685C203014093 @default.
• W2023808685 hasConceptScore W2023808685C207001950 @default.
• W2023808685 hasConceptScore W2023808685C2778453870 @default.
• W2023808685 hasConceptScore W2023808685C2778461978 @default.
• W2023808685 hasConceptScore W2023808685C2780007613 @default.
• W2023808685 hasConceptScore W2023808685C2780017796 @default.
• W2023808685 hasConceptScore W2023808685C2780931953 @default.
• W2023808685 hasConceptScore W2023808685C28328180 @default.
• W2023808685 hasConceptScore W2023808685C502942594 @default.
• W2023808685 hasConceptScore W2023808685C54355233 @default.
• W2023808685 hasConceptScore W2023808685C55493867 @default.
• W2023808685 hasConceptScore W2023808685C81885089 @default.
• W2023808685 hasConceptScore W2023808685C86803240 @default.
• W2023808685 hasConceptScore W2023808685C95444343 @default.
• W2023808685 hasIssue "12" @default.
• W2023808685 hasLocation W20238086851 @default.
• W2023808685 hasLocation W20238086852 @default.
• W2023808685 hasOpenAccess W2023808685 @default.
• W2023808685 hasPrimaryLocation W20238086851 @default.
• W2023808685 hasRelatedWork W1542394131 @default.
• W2023808685 hasRelatedWork W1989423350 @default.
• W2023808685 hasRelatedWork W2086559454 @default.
• W2023808685 hasRelatedWork W2177185177 @default.
• W2023808685 hasRelatedWork W2314522894 @default.
• W2023808685 hasRelatedWork W2402457869 @default.
• W2023808685 hasRelatedWork W2414959262 @default.
• W2023808685 hasRelatedWork W2462776261 @default.
• W2023808685 hasRelatedWork W2908179880 @default.
• W2023808685 hasRelatedWork W304985165 @default.
• W2023808685 hasVolume "9" @default.
• W2023808685 isParatext "false" @default.
• W2023808685 isRetracted "false" @default.
• W2023808685 magId "2023808685" @default.
• W2023808685 workType "article" @default.