Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023809088> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2023809088 endingPage "365" @default.
- W2023809088 startingPage "363" @default.
- W2023809088 abstract "Dexamethasone treated rats inoculated with Trypanosoma cruzi developed acute parasitemia. In addition, these animals concomitantly developed severe Pneumocystis carinii pneumonia (PCP) and died after 4 weeks of immunosuppression (100%). However, immunocompetent (untreated) rats inoculated with T. cruzi did not acquire P. carinii and recovered from T. cruzi infection. Rats immunosuppressed, but not inoculated with T. cruzi, developed only PCP and died 5-6 weeks later (93%). In contrast, immunocompetent or immunocompromised IRC mice infected with T. cruzi all died of acute parasitemia in only 8-12 days with no detectable PCP infection. In conclusion, rats immunosuppressed and T. cruzi inoculated can serve as a MOPPS model for a single drug evaluation. In addition, T. cruzi infection independently does not provoke P. carinii pneumonia in this model. Finally, patients with Chagas' disease treated with corticosteroids may be at risk for PCP and should be considered for chemoprophylaxis." @default.
- W2023809088 created "2016-06-24" @default.
- W2023809088 creator A5000121920 @default.
- W2023809088 creator A5006265191 @default.
- W2023809088 creator A5044035073 @default.
- W2023809088 date "2000-12-01" @default.
- W2023809088 modified "2023-09-27" @default.
- W2023809088 title "A rat model for combined Trypanosoma cruzi and Pneumocystis carinii infection" @default.
- W2023809088 cites W1835562422 @default.
- W2023809088 cites W2018109638 @default.
- W2023809088 cites W2049102964 @default.
- W2023809088 cites W2060175827 @default.
- W2023809088 cites W2124797956 @default.
- W2023809088 cites W2127262105 @default.
- W2023809088 cites W2326164692 @default.
- W2023809088 cites W2441519520 @default.
- W2023809088 doi "https://doi.org/10.1006/mpat.2000.0402" @default.
- W2023809088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11095921" @default.
- W2023809088 hasPublicationYear "2000" @default.
- W2023809088 type Work @default.
- W2023809088 sameAs 2023809088 @default.
- W2023809088 citedByCount "3" @default.
- W2023809088 countsByYear W20238090882014 @default.
- W2023809088 countsByYear W20238090882015 @default.
- W2023809088 countsByYear W20238090882023 @default.
- W2023809088 crossrefType "journal-article" @default.
- W2023809088 hasAuthorship W2023809088A5000121920 @default.
- W2023809088 hasAuthorship W2023809088A5006265191 @default.
- W2023809088 hasAuthorship W2023809088A5044035073 @default.
- W2023809088 hasConcept C112418997 @default.
- W2023809088 hasConcept C126322002 @default.
- W2023809088 hasConcept C136764020 @default.
- W2023809088 hasConcept C159047783 @default.
- W2023809088 hasConcept C180032290 @default.
- W2023809088 hasConcept C203014093 @default.
- W2023809088 hasConcept C2775867548 @default.
- W2023809088 hasConcept C2776688490 @default.
- W2023809088 hasConcept C2777559004 @default.
- W2023809088 hasConcept C2777625466 @default.
- W2023809088 hasConcept C2777914695 @default.
- W2023809088 hasConcept C2778048844 @default.
- W2023809088 hasConcept C2778371730 @default.
- W2023809088 hasConcept C2780252810 @default.
- W2023809088 hasConcept C2993443204 @default.
- W2023809088 hasConcept C41008148 @default.
- W2023809088 hasConcept C71924100 @default.
- W2023809088 hasConcept C71928629 @default.
- W2023809088 hasConcept C86803240 @default.
- W2023809088 hasConcept C89423630 @default.
- W2023809088 hasConceptScore W2023809088C112418997 @default.
- W2023809088 hasConceptScore W2023809088C126322002 @default.
- W2023809088 hasConceptScore W2023809088C136764020 @default.
- W2023809088 hasConceptScore W2023809088C159047783 @default.
- W2023809088 hasConceptScore W2023809088C180032290 @default.
- W2023809088 hasConceptScore W2023809088C203014093 @default.
- W2023809088 hasConceptScore W2023809088C2775867548 @default.
- W2023809088 hasConceptScore W2023809088C2776688490 @default.
- W2023809088 hasConceptScore W2023809088C2777559004 @default.
- W2023809088 hasConceptScore W2023809088C2777625466 @default.
- W2023809088 hasConceptScore W2023809088C2777914695 @default.
- W2023809088 hasConceptScore W2023809088C2778048844 @default.
- W2023809088 hasConceptScore W2023809088C2778371730 @default.
- W2023809088 hasConceptScore W2023809088C2780252810 @default.
- W2023809088 hasConceptScore W2023809088C2993443204 @default.
- W2023809088 hasConceptScore W2023809088C41008148 @default.
- W2023809088 hasConceptScore W2023809088C71924100 @default.
- W2023809088 hasConceptScore W2023809088C71928629 @default.
- W2023809088 hasConceptScore W2023809088C86803240 @default.
- W2023809088 hasConceptScore W2023809088C89423630 @default.
- W2023809088 hasIssue "6" @default.
- W2023809088 hasLocation W20238090881 @default.
- W2023809088 hasLocation W20238090882 @default.
- W2023809088 hasOpenAccess W2023809088 @default.
- W2023809088 hasPrimaryLocation W20238090881 @default.
- W2023809088 hasRelatedWork W1982245052 @default.
- W2023809088 hasRelatedWork W1984298847 @default.
- W2023809088 hasRelatedWork W2008330865 @default.
- W2023809088 hasRelatedWork W2023809088 @default.
- W2023809088 hasRelatedWork W2053593320 @default.
- W2023809088 hasRelatedWork W2145659413 @default.
- W2023809088 hasRelatedWork W2341079596 @default.
- W2023809088 hasRelatedWork W2409569085 @default.
- W2023809088 hasRelatedWork W3187048474 @default.
- W2023809088 hasRelatedWork W2187132627 @default.
- W2023809088 hasVolume "29" @default.
- W2023809088 isParatext "false" @default.
- W2023809088 isRetracted "false" @default.
- W2023809088 magId "2023809088" @default.
- W2023809088 workType "article" @default.