Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023809817> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2023809817 endingPage "323" @default.
- W2023809817 startingPage "315" @default.
- W2023809817 abstract "Racemic methadone (MET) is administered to heroin users undergoing methadone maintenance therapy (MMT) in Australia. The enantiomers of methadone possess different pharmacological effects, and the enantioselective metabolism of methadone to its two major metabolites, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP) has been demonstrated. Therefore, a stereoselective method capable of quantifying methadone, EDDP and EMDP in biological samples could be of benefit in the monitoring of MMT patients. In particular, the analysis of hair samples would provide a means by which long-term monitoring of MMT patients could be achieved. To date, no HPLC method has been published for the simultaneous separation of the six enantiomers. A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the chiral analysis of methadone, EDDP and EMDP was developed using an α-glycoprotein (AGP) stationary phase. The method development involved the utilisation of factorial analysis experimental designs and the application of artificial neural networks (ANNs) to model the chromatographic response surfaces. The optimal conditions were determined to be 20 mM acetic acid: isopropanol (93:7, pH 7.4), with a flow rate of 0.9 mL/min. The method was validated and subsequently applied to the analysis of 20 hair samples collected from MMT patients." @default.
- W2023809817 created "2016-06-24" @default.
- W2023809817 creator A5004658580 @default.
- W2023809817 creator A5032247134 @default.
- W2023809817 creator A5085604711 @default.
- W2023809817 date "2005-01-25" @default.
- W2023809817 modified "2023-09-23" @default.
- W2023809817 title "Chiral analysis of methadone and its major metabolites (EDDP and EMDP) by liquid chromatography–mass spectrometry" @default.
- W2023809817 cites W1497037168 @default.
- W2023809817 cites W1516221483 @default.
- W2023809817 cites W1554663460 @default.
- W2023809817 cites W1568516461 @default.
- W2023809817 cites W1608292140 @default.
- W2023809817 cites W1620696885 @default.
- W2023809817 cites W1970637929 @default.
- W2023809817 cites W2004951600 @default.
- W2023809817 cites W2005283267 @default.
- W2023809817 cites W2026569186 @default.
- W2023809817 cites W2029906878 @default.
- W2023809817 cites W2035615045 @default.
- W2023809817 cites W2048062321 @default.
- W2023809817 cites W2063916324 @default.
- W2023809817 cites W2072462334 @default.
- W2023809817 cites W2073872864 @default.
- W2023809817 cites W2084108654 @default.
- W2023809817 cites W2091257941 @default.
- W2023809817 cites W2125207367 @default.
- W2023809817 cites W2147598221 @default.
- W2023809817 cites W2331611171 @default.
- W2023809817 cites W2333750047 @default.
- W2023809817 cites W2988273661 @default.
- W2023809817 doi "https://doi.org/10.1016/j.jchromb.2004.10.053" @default.
- W2023809817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15639454" @default.
- W2023809817 hasPublicationYear "2005" @default.
- W2023809817 type Work @default.
- W2023809817 sameAs 2023809817 @default.
- W2023809817 citedByCount "51" @default.
- W2023809817 countsByYear W20238098172012 @default.
- W2023809817 countsByYear W20238098172013 @default.
- W2023809817 countsByYear W20238098172014 @default.
- W2023809817 countsByYear W20238098172015 @default.
- W2023809817 countsByYear W20238098172016 @default.
- W2023809817 countsByYear W20238098172018 @default.
- W2023809817 countsByYear W20238098172019 @default.
- W2023809817 countsByYear W20238098172020 @default.
- W2023809817 crossrefType "journal-article" @default.
- W2023809817 hasAuthorship W2023809817A5004658580 @default.
- W2023809817 hasAuthorship W2023809817A5032247134 @default.
- W2023809817 hasAuthorship W2023809817A5085604711 @default.
- W2023809817 hasConcept C162356407 @default.
- W2023809817 hasConcept C16838498 @default.
- W2023809817 hasConcept C178790620 @default.
- W2023809817 hasConcept C179998833 @default.
- W2023809817 hasConcept C185592680 @default.
- W2023809817 hasConcept C2778767360 @default.
- W2023809817 hasConcept C31827203 @default.
- W2023809817 hasConcept C43617362 @default.
- W2023809817 hasConcept C486523 @default.
- W2023809817 hasConcept C64489805 @default.
- W2023809817 hasConcept C71924100 @default.
- W2023809817 hasConcept C98274493 @default.
- W2023809817 hasConceptScore W2023809817C162356407 @default.
- W2023809817 hasConceptScore W2023809817C16838498 @default.
- W2023809817 hasConceptScore W2023809817C178790620 @default.
- W2023809817 hasConceptScore W2023809817C179998833 @default.
- W2023809817 hasConceptScore W2023809817C185592680 @default.
- W2023809817 hasConceptScore W2023809817C2778767360 @default.
- W2023809817 hasConceptScore W2023809817C31827203 @default.
- W2023809817 hasConceptScore W2023809817C43617362 @default.
- W2023809817 hasConceptScore W2023809817C486523 @default.
- W2023809817 hasConceptScore W2023809817C64489805 @default.
- W2023809817 hasConceptScore W2023809817C71924100 @default.
- W2023809817 hasConceptScore W2023809817C98274493 @default.
- W2023809817 hasIssue "2" @default.
- W2023809817 hasLocation W20238098171 @default.
- W2023809817 hasLocation W20238098172 @default.
- W2023809817 hasOpenAccess W2023809817 @default.
- W2023809817 hasPrimaryLocation W20238098171 @default.
- W2023809817 hasRelatedWork W2008851809 @default.
- W2023809817 hasRelatedWork W2021792606 @default.
- W2023809817 hasRelatedWork W2025925626 @default.
- W2023809817 hasRelatedWork W2048027784 @default.
- W2023809817 hasRelatedWork W2166263961 @default.
- W2023809817 hasRelatedWork W2314648110 @default.
- W2023809817 hasRelatedWork W2351189302 @default.
- W2023809817 hasRelatedWork W2787820172 @default.
- W2023809817 hasRelatedWork W2793681862 @default.
- W2023809817 hasRelatedWork W3188441070 @default.
- W2023809817 hasVolume "814" @default.
- W2023809817 isParatext "false" @default.
- W2023809817 isRetracted "false" @default.
- W2023809817 magId "2023809817" @default.
- W2023809817 workType "article" @default.