FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023812148> ?p ?o ?g. }

• W2023812148 abstract "Monitoring the presence, production and transport of proteins inside individual living cells can provide vital information about cellular signaling pathways and the overall biological response of an organism. For example, cellular response to external stimuli, such as biological warfare (BW) agents, can be monitored by measuring interleukin-II (IL-2) expression inside T-cells as well as other chemical species associated with T-cell activation. By monitoring such species, pre-symptomatic detection of exposure to BW agents can be achieved, leading to significantly increased post-exposure survival rates. To accomplish such monitoring, we have developed and optimized implantable nanosphere-based nanosensors for the intracellular analysis of specific proteins in a label-free fashion. These sensors consist of 300-520 nm diameter silica spheres that have been coated with silver and antibodies to allow for trace protein detection via surface enhanced Raman spectroscopy (SERS). They have been optimized for SERS response by evaluating the size of the nanospheres best suited to 632.8 nm laser excitation, as well as the various nanosensor fabrication steps (i.e., silver deposition process, antibody binding, etc.). During usage, the presence of the specific protein of interest is monitored by either directly measuring SERS signals associated with the protein and/or changes in the SERS spectrum of the antibodies resulting from conformational changes after antigen binding. In this work, human insulin was used as a model compound for initial studies into the sensitivity of these optimized nanosensors." @default.
• W2023812148 created "2016-06-24" @default.
• W2023812148 creator A5054664866 @default.
• W2023812148 creator A5065055118 @default.
• W2023812148 creator A5070861783 @default.
• W2023812148 date "2005-11-09" @default.
• W2023812148 modified "2023-10-16" @default.
• W2023812148 title "Label-free detection of antigens using implantable SERS nanosensors" @default.
• W2023812148 cites W1593350445 @default.
• W2023812148 cites W1665957897 @default.
• W2023812148 cites W1969366288 @default.
• W2023812148 cites W1970718457 @default.
• W2023812148 cites W1974032083 @default.
• W2023812148 cites W1974363564 @default.
• W2023812148 cites W1975787310 @default.
• W2023812148 cites W1979034971 @default.
• W2023812148 cites W1979216766 @default.
• W2023812148 cites W1980116113 @default.
• W2023812148 cites W1981667444 @default.
• W2023812148 cites W1983837961 @default.
• W2023812148 cites W1984069149 @default.
• W2023812148 cites W1988886789 @default.
• W2023812148 cites W1998637429 @default.
• W2023812148 cites W2000731965 @default.
• W2023812148 cites W2002801807 @default.
• W2023812148 cites W2004988150 @default.
• W2023812148 cites W2005367375 @default.
• W2023812148 cites W2009271486 @default.
• W2023812148 cites W2009488006 @default.
• W2023812148 cites W2011166834 @default.
• W2023812148 cites W2012975097 @default.
• W2023812148 cites W2014133708 @default.
• W2023812148 cites W2021980355 @default.
• W2023812148 cites W2022130063 @default.
• W2023812148 cites W2022765285 @default.
• W2023812148 cites W2024446197 @default.
• W2023812148 cites W2030925580 @default.
• W2023812148 cites W2034385243 @default.
• W2023812148 cites W2037487228 @default.
• W2023812148 cites W2039246404 @default.
• W2023812148 cites W2042046620 @default.
• W2023812148 cites W2046349548 @default.
• W2023812148 cites W2048847493 @default.
• W2023812148 cites W2049094614 @default.
• W2023812148 cites W2051361463 @default.
• W2023812148 cites W2054220842 @default.
• W2023812148 cites W2055516334 @default.
• W2023812148 cites W2057428057 @default.
• W2023812148 cites W2059099265 @default.
• W2023812148 cites W2063343818 @default.
• W2023812148 cites W2071505311 @default.
• W2023812148 cites W2072278940 @default.
• W2023812148 cites W2074379564 @default.
• W2023812148 cites W2074623710 @default.
• W2023812148 cites W2081692065 @default.
• W2023812148 cites W2082153466 @default.
• W2023812148 cites W2083410689 @default.
• W2023812148 cites W2084292064 @default.
• W2023812148 cites W2086018869 @default.
• W2023812148 cites W2086971829 @default.
• W2023812148 cites W2089110091 @default.
• W2023812148 cites W2090470592 @default.
• W2023812148 cites W2093850300 @default.
• W2023812148 cites W2093913522 @default.
• W2023812148 cites W2124303031 @default.
• W2023812148 cites W2147436136 @default.
• W2023812148 cites W2151630962 @default.
• W2023812148 cites W2167869430 @default.
• W2023812148 cites W2171512908 @default.
• W2023812148 cites W2238928914 @default.
• W2023812148 cites W2338909191 @default.
• W2023812148 cites W2496233075 @default.
• W2023812148 cites W2525736717 @default.
• W2023812148 cites W2751440259 @default.
• W2023812148 cites W3025105508 @default.
• W2023812148 cites W331933503 @default.
• W2023812148 doi "https://doi.org/10.1117/12.629205" @default.
• W2023812148 hasPublicationYear "2005" @default.
• W2023812148 type Work @default.
• W2023812148 sameAs 2023812148 @default.
• W2023812148 citedByCount "3" @default.
• W2023812148 countsByYear W20238121482012 @default.
• W2023812148 crossrefType "proceedings-article" @default.
• W2023812148 hasAuthorship W2023812148A5054664866 @default.
• W2023812148 hasAuthorship W2023812148A5065055118 @default.
• W2023812148 hasAuthorship W2023812148A5070861783 @default.
• W2023812148 hasConcept C171250308 @default.
• W2023812148 hasConcept C192562407 @default.
• W2023812148 hasConcept C41008148 @default.
• W2023812148 hasConcept C41858301 @default.
• W2023812148 hasConceptScore W2023812148C171250308 @default.
• W2023812148 hasConceptScore W2023812148C192562407 @default.
• W2023812148 hasConceptScore W2023812148C41008148 @default.
• W2023812148 hasConceptScore W2023812148C41858301 @default.
• W2023812148 hasLocation W20238121481 @default.
• W2023812148 hasOpenAccess W2023812148 @default.
• W2023812148 hasPrimaryLocation W20238121481 @default.
• W2023812148 hasRelatedWork W1510448010 @default.
• W2023812148 hasRelatedWork W1559608182 @default.
• W2023812148 hasRelatedWork W2137577343 @default.

• next