Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023814388> ?p ?o ?g. }
- W2023814388 endingPage "637" @default.
- W2023814388 startingPage "631" @default.
- W2023814388 abstract "Our previous study demonstrated that the aortic inducible nitric oxide synthase (iNOS) expression and the plasma nitrite level in spontaneously hypertensive rats (SHR) were greater than that in age-matched Wistar-Kyoto rats (WKY). We subsequently hypothesized that the over-expression of iNOS might play an important role in the pathogenesis of hypertension in SHR. In the present study, pyrrolidinedithiocarbamate (PDTC, 10 mg kg−1 day−1, p.o., antioxidant and nuclear factor-κ B inhibitor) and aminoguanidine (15 mg kg−1 day−1, p.o., selective inhibitor of iNOS) was used to treat SHR and WKY from age of 5 weeks through 16 weeks. We found that PDTC and aminoguanidine significantly suppressed the development of hypertension and improved the diminished vascular responses to acetylcholine in SHR but not in WKY. Likewise, the increase of iNOS expression, nitrotyrosine immunostaining, nitric oxide production and superoxide anion formation in adult SHR were also significantly suppressed by chronic treatment with PDTC and aminoguanidine. In conclusion, this study demonstrated that both PDTC and aminoguanidine significantly attenuated the development of hypertension in SHR. The results suggest that PDTC suppresses iNOS expression due to its anti-oxidant and/or nuclear factor-κ B inhibitory properties. However, the effect of aminoguanidine was predominantly mediated by inhibition of iNOS activity, thereby reducing peroxynitrite formation. We propose that the development of a more specific and potent inhibitor of iNOS might be beneficial in preventing pathological conditions such as the essential hypertension. British Journal of Pharmacology (2000) 131, 631–637; doi:10.1038/sj.bjp.0703603" @default.
- W2023814388 created "2016-06-24" @default.
- W2023814388 creator A5019983473 @default.
- W2023814388 creator A5042940334 @default.
- W2023814388 creator A5060525354 @default.
- W2023814388 date "2000-10-01" @default.
- W2023814388 modified "2023-10-01" @default.
- W2023814388 title "Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase" @default.
- W2023814388 cites W1964527864 @default.
- W2023814388 cites W1968599987 @default.
- W2023814388 cites W1990390910 @default.
- W2023814388 cites W1990525267 @default.
- W2023814388 cites W1994495762 @default.
- W2023814388 cites W1994950364 @default.
- W2023814388 cites W2002069556 @default.
- W2023814388 cites W2012978126 @default.
- W2023814388 cites W2019843852 @default.
- W2023814388 cites W2020024424 @default.
- W2023814388 cites W2031375858 @default.
- W2023814388 cites W2035199836 @default.
- W2023814388 cites W2039531860 @default.
- W2023814388 cites W2042519036 @default.
- W2023814388 cites W2052855638 @default.
- W2023814388 cites W2055881144 @default.
- W2023814388 cites W2058137293 @default.
- W2023814388 cites W2061286203 @default.
- W2023814388 cites W2063267156 @default.
- W2023814388 cites W2067755978 @default.
- W2023814388 cites W2076103833 @default.
- W2023814388 cites W2081148711 @default.
- W2023814388 cites W2093636423 @default.
- W2023814388 cites W2096678608 @default.
- W2023814388 cites W2120670639 @default.
- W2023814388 cites W2121282237 @default.
- W2023814388 cites W2122479313 @default.
- W2023814388 cites W2135633069 @default.
- W2023814388 cites W2141719916 @default.
- W2023814388 cites W2159567970 @default.
- W2023814388 cites W2160496529 @default.
- W2023814388 cites W2280107793 @default.
- W2023814388 doi "https://doi.org/10.1038/sj.bjp.0703603" @default.
- W2023814388 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1572360" @default.
- W2023814388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11015317" @default.
- W2023814388 hasPublicationYear "2000" @default.
- W2023814388 type Work @default.
- W2023814388 sameAs 2023814388 @default.
- W2023814388 citedByCount "98" @default.
- W2023814388 countsByYear W20238143882012 @default.
- W2023814388 countsByYear W20238143882013 @default.
- W2023814388 countsByYear W20238143882014 @default.
- W2023814388 countsByYear W20238143882015 @default.
- W2023814388 countsByYear W20238143882016 @default.
- W2023814388 countsByYear W20238143882017 @default.
- W2023814388 countsByYear W20238143882018 @default.
- W2023814388 countsByYear W20238143882019 @default.
- W2023814388 countsByYear W20238143882020 @default.
- W2023814388 countsByYear W20238143882021 @default.
- W2023814388 countsByYear W20238143882022 @default.
- W2023814388 countsByYear W20238143882023 @default.
- W2023814388 crossrefType "journal-article" @default.
- W2023814388 hasAuthorship W2023814388A5019983473 @default.
- W2023814388 hasAuthorship W2023814388A5042940334 @default.
- W2023814388 hasAuthorship W2023814388A5060525354 @default.
- W2023814388 hasBestOaLocation W20238143882 @default.
- W2023814388 hasConcept C126322002 @default.
- W2023814388 hasConcept C134018914 @default.
- W2023814388 hasConcept C181199279 @default.
- W2023814388 hasConcept C185592680 @default.
- W2023814388 hasConcept C2776914184 @default.
- W2023814388 hasConcept C2777622882 @default.
- W2023814388 hasConcept C2777730290 @default.
- W2023814388 hasConcept C2778326061 @default.
- W2023814388 hasConcept C2778784160 @default.
- W2023814388 hasConcept C2779385521 @default.
- W2023814388 hasConcept C2779698670 @default.
- W2023814388 hasConcept C2780795997 @default.
- W2023814388 hasConcept C2780942790 @default.
- W2023814388 hasConcept C2780983412 @default.
- W2023814388 hasConcept C519581460 @default.
- W2023814388 hasConcept C55493867 @default.
- W2023814388 hasConcept C71924100 @default.
- W2023814388 hasConcept C98274493 @default.
- W2023814388 hasConceptScore W2023814388C126322002 @default.
- W2023814388 hasConceptScore W2023814388C134018914 @default.
- W2023814388 hasConceptScore W2023814388C181199279 @default.
- W2023814388 hasConceptScore W2023814388C185592680 @default.
- W2023814388 hasConceptScore W2023814388C2776914184 @default.
- W2023814388 hasConceptScore W2023814388C2777622882 @default.
- W2023814388 hasConceptScore W2023814388C2777730290 @default.
- W2023814388 hasConceptScore W2023814388C2778326061 @default.
- W2023814388 hasConceptScore W2023814388C2778784160 @default.
- W2023814388 hasConceptScore W2023814388C2779385521 @default.
- W2023814388 hasConceptScore W2023814388C2779698670 @default.
- W2023814388 hasConceptScore W2023814388C2780795997 @default.
- W2023814388 hasConceptScore W2023814388C2780942790 @default.
- W2023814388 hasConceptScore W2023814388C2780983412 @default.
- W2023814388 hasConceptScore W2023814388C519581460 @default.
- W2023814388 hasConceptScore W2023814388C55493867 @default.