Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023821341> ?p ?o ?g. }
- W2023821341 endingPage "e46607" @default.
- W2023821341 startingPage "e46607" @default.
- W2023821341 abstract "While functional imaging is widely used in studies of the brain, how well the hemodynamic signal represents the underlying neural activity is still unclear. And there is a debate on whether hemodynamic signal is more tightly related to synaptic activity or action potentials. This study intends to address these questions by examining neurovascular coupling driven by pyramidal cells in the motor cortex of rats. Pyramidal cells in the motor cortex of rats were selectively transduced with the light sensitive cation channel channelrhodopsin-2 (ChR2). Electrophysiological recordings and optical intrinsic signal imaging were performed simultaneously and synchronously to capture the neural activity and hemodynamics induced by optical stimulation of ChR2-expressing pyramidal cells. Our results indicate that both synaptic activity (local field potential, LFP) and action potentials (multi-unit activity, MUA) are tightly related to hemodynamic signals. While LFPs in γ band are better in predicting hemodynamic signals elicited by short stimuli, MUA has better predictions to hemodynamic signals elicited by long stimuli. Our results also indicate that strong nonlinearity exists in neurovascular coupling." @default.
- W2023821341 created "2016-06-24" @default.
- W2023821341 creator A5017888734 @default.
- W2023821341 creator A5037514199 @default.
- W2023821341 creator A5053409187 @default.
- W2023821341 creator A5060239424 @default.
- W2023821341 creator A5081484066 @default.
- W2023821341 creator A5087268135 @default.
- W2023821341 creator A5089239184 @default.
- W2023821341 date "2012-09-28" @default.
- W2023821341 modified "2023-09-27" @default.
- W2023821341 title "Cortical Neurovascular Coupling Driven by Stimulation of Channelrhodopsin-2" @default.
- W2023821341 cites W1556483602 @default.
- W2023821341 cites W1964641657 @default.
- W2023821341 cites W1967646528 @default.
- W2023821341 cites W1979240985 @default.
- W2023821341 cites W1980337522 @default.
- W2023821341 cites W1986410986 @default.
- W2023821341 cites W1998400247 @default.
- W2023821341 cites W2000137090 @default.
- W2023821341 cites W2003739479 @default.
- W2023821341 cites W2003912393 @default.
- W2023821341 cites W2021704325 @default.
- W2023821341 cites W2025919881 @default.
- W2023821341 cites W2028434676 @default.
- W2023821341 cites W2031173074 @default.
- W2023821341 cites W2036962817 @default.
- W2023821341 cites W2059112781 @default.
- W2023821341 cites W2065459990 @default.
- W2023821341 cites W2068584514 @default.
- W2023821341 cites W2069527505 @default.
- W2023821341 cites W2072739064 @default.
- W2023821341 cites W2089495387 @default.
- W2023821341 cites W2096364103 @default.
- W2023821341 cites W2103681669 @default.
- W2023821341 cites W2105220251 @default.
- W2023821341 cites W2106193847 @default.
- W2023821341 cites W2111609296 @default.
- W2023821341 cites W2114104729 @default.
- W2023821341 cites W2135216474 @default.
- W2023821341 cites W2137523819 @default.
- W2023821341 cites W2139354009 @default.
- W2023821341 cites W2142205905 @default.
- W2023821341 cites W2148331740 @default.
- W2023821341 cites W2148992333 @default.
- W2023821341 cites W2154840243 @default.
- W2023821341 cites W2154973010 @default.
- W2023821341 cites W2158550713 @default.
- W2023821341 cites W2163815564 @default.
- W2023821341 cites W2166512953 @default.
- W2023821341 cites W2167095271 @default.
- W2023821341 cites W281186777 @default.
- W2023821341 doi "https://doi.org/10.1371/journal.pone.0046607" @default.
- W2023821341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3460925" @default.
- W2023821341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23029556" @default.
- W2023821341 hasPublicationYear "2012" @default.
- W2023821341 type Work @default.
- W2023821341 sameAs 2023821341 @default.
- W2023821341 citedByCount "14" @default.
- W2023821341 countsByYear W20238213412014 @default.
- W2023821341 countsByYear W20238213412015 @default.
- W2023821341 countsByYear W20238213412016 @default.
- W2023821341 countsByYear W20238213412017 @default.
- W2023821341 countsByYear W20238213412018 @default.
- W2023821341 countsByYear W20238213412020 @default.
- W2023821341 countsByYear W20238213412021 @default.
- W2023821341 crossrefType "journal-article" @default.
- W2023821341 hasAuthorship W2023821341A5017888734 @default.
- W2023821341 hasAuthorship W2023821341A5037514199 @default.
- W2023821341 hasAuthorship W2023821341A5053409187 @default.
- W2023821341 hasAuthorship W2023821341A5060239424 @default.
- W2023821341 hasAuthorship W2023821341A5081484066 @default.
- W2023821341 hasAuthorship W2023821341A5087268135 @default.
- W2023821341 hasAuthorship W2023821341A5089239184 @default.
- W2023821341 hasBestOaLocation W20238213411 @default.
- W2023821341 hasConcept C105572291 @default.
- W2023821341 hasConcept C105702510 @default.
- W2023821341 hasConcept C117838684 @default.
- W2023821341 hasConcept C126322002 @default.
- W2023821341 hasConcept C131584629 @default.
- W2023821341 hasConcept C15744967 @default.
- W2023821341 hasConcept C169760540 @default.
- W2023821341 hasConcept C178853913 @default.
- W2023821341 hasConcept C185263204 @default.
- W2023821341 hasConcept C185592680 @default.
- W2023821341 hasConcept C191897082 @default.
- W2023821341 hasConcept C192562407 @default.
- W2023821341 hasConcept C24998067 @default.
- W2023821341 hasConcept C26170363 @default.
- W2023821341 hasConcept C2777953023 @default.
- W2023821341 hasConcept C2778373776 @default.
- W2023821341 hasConcept C2779345533 @default.
- W2023821341 hasConcept C2780307956 @default.
- W2023821341 hasConcept C2781347215 @default.
- W2023821341 hasConcept C42219234 @default.
- W2023821341 hasConcept C50738837 @default.
- W2023821341 hasConcept C71924100 @default.
- W2023821341 hasConcept C84393581 @default.