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- W2023821454 abstract "The 96-h median lethal dose (LD50; dose that is lethal to 50% of test organisms) of cyclopiazonic acid (CPA) injected intraperitoneally (IP) into channel catfish Ictalurus punctatus (average weight, 19 g) was 2.82 mg/kg of body weight, with a 95% confidence interval of 2.483.12 mg/kg. The acute effects of CPA were characteristic of a neurotoxin. Some fish injected with CPA doses of 2.40 mg/kg of body weight or higher showed severe convulsions, tetany, and death within 30 min postinjection. There were no lesions in the organs of the moribund fish examined grossly and histologically. Cyclopiazonic acid fed for 10 weeks at a concentration of 100 μg/kg of diet had a growth-suppressing effect (P < 0.05) on channel catfish (average weight, 7.5 g), and a concentration of 10,000 μg/kg caused accumulation of proteinaceous granules in renal tubular epithelium and necrosis of gastric glands. Cyclopiazonic acid had no effects on hematocrit, hemoglobin concentration, and erythrocyte and leukocyte counts (P > 0.05)." @default.
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- W2023821454 date "1990-12-01" @default.
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- W2023821454 title "Acute and Subchronic Toxicity of Cyclopiazonic Acid to Channel Catfish" @default.
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- W2023821454 doi "https://doi.org/10.1577/1548-8667(1990)002<0255:aastoc>2.3.co;2" @default.
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