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- W2023821541 endingPage "130" @default.
- W2023821541 startingPage "123" @default.
- W2023821541 abstract "Luteinizing hormone-releasing hormone (LHRH) was first isolated in the mammalian hypothalamus and shown to be the primary regulator of the reproductive system through its initiation of pituitary gonadotropin release. Since its discovery, this form of LHRH (LHRH-I) has been shown to be one of many structural variants with a variety of roles in both the brain and peripheral tissues. Enormous interest has been focused on LHRH-I and LHRH-II and their cognate receptors as targets for designing therapies to treat cancers of the reproductive system. LHRH-I is processed by a zinc metalloendopeptidase EC 3.4.24.15 (EP24.15) that cleaves the hormone at the fifth and sixth bond of the decapeptide (Tyr 5 -Gly 6 ) to form LHRH-( 1 – 5 ). We have previously reported that the autoregulation of LHRH gene expression can also be mediated by its processed peptide, LHRH-( 1 – 5 ). Furthermore, LHRH-( 1 – 5 ) has also been shown to be involved in cell proliferation. This review will focus on the possible roles of LHRH and its processed peptide, LHRH-( 1 – 5 ), in non-hypothalamic tissues." @default.
- W2023821541 created "2016-06-24" @default.
- W2023821541 creator A5012568837 @default.
- W2023821541 creator A5046082760 @default.
- W2023821541 creator A5063689427 @default.
- W2023821541 creator A5067933431 @default.
- W2023821541 creator A5082208671 @default.
- W2023821541 date "2008-02-01" @default.
- W2023821541 modified "2023-10-11" @default.
- W2023821541 title "Luteinizing Hormone-Releasing Hormone I (LHRH-I) and Its Metabolite in Peripheral Tissues" @default.
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