Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023821696> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2023821696 abstract "At least 15–20 million persons in Latin America are infected with leishmaniasis, with 2 million new cases each year [1]. Plants are a potential source of new antiprotozoal drugs [2]. Copaiba oil has been used in folk medicine as an anti-inflammatory, antitumor, wound-cicatrisation, antinociceptive, and antimicrobial [3]. In this study, the biological effects of oil resin from Copaifera reticulata against axenic amastigote forms of Leishmania amazonensis were evaluated. The antiproliferative effect was determined by direct counting of the cells in a Neubauer chamber. The survival index was determined, to evaluate the effect of the copaiba oil on intracellular amastigotes. Morphological and ultrastructural alterations of axenic amastigote forms treated with copaiba oil were analyzed by scanning and transmission electron microscopy. The antiproliferative assays showed a dose-dependent effect, with IC50/72h values for axenic amastigote of 15µg/ml. The internalisation index reflected a decrease of 47.7% when treated with 20µg/ml, compared to the control. Transmission electron microscopy showed the presence of myelin-like figures, appearance of autophagic structures, and formation of exocytic projections in the flagellar pocket. Axenic amastigotes of L. amazonensis treated with oil underwent remarkable morphological alterations, with rupture of the plasma membrane, as observed by scanning electron microscopy. Based on these results, copaiba oils appear to have potential as an alternative treatment for leishmaniasis." @default.
- W2023821696 created "2016-06-24" @default.
- W2023821696 creator A5035431030 @default.
- W2023821696 creator A5051831044 @default.
- W2023821696 creator A5068122908 @default.
- W2023821696 creator A5068761633 @default.
- W2023821696 creator A5082037076 @default.
- W2023821696 creator A5089763580 @default.
- W2023821696 date "2008-07-01" @default.
- W2023821696 modified "2023-09-23" @default.
- W2023821696 title "Effect of Copaifera reticulata on amastigote forms of Leishmania (L.) amazonensis" @default.
- W2023821696 doi "https://doi.org/10.1055/s-0028-1084150" @default.
- W2023821696 hasPublicationYear "2008" @default.
- W2023821696 type Work @default.
- W2023821696 sameAs 2023821696 @default.
- W2023821696 citedByCount "0" @default.
- W2023821696 crossrefType "journal-article" @default.
- W2023821696 hasAuthorship W2023821696A5035431030 @default.
- W2023821696 hasAuthorship W2023821696A5051831044 @default.
- W2023821696 hasAuthorship W2023821696A5068122908 @default.
- W2023821696 hasAuthorship W2023821696A5068761633 @default.
- W2023821696 hasAuthorship W2023821696A5082037076 @default.
- W2023821696 hasAuthorship W2023821696A5089763580 @default.
- W2023821696 hasConcept C136764020 @default.
- W2023821696 hasConcept C185592680 @default.
- W2023821696 hasConcept C202751555 @default.
- W2023821696 hasConcept C203014093 @default.
- W2023821696 hasConcept C2776555147 @default.
- W2023821696 hasConcept C2776635100 @default.
- W2023821696 hasConcept C2778265057 @default.
- W2023821696 hasConcept C2781092759 @default.
- W2023821696 hasConcept C41008148 @default.
- W2023821696 hasConcept C523546767 @default.
- W2023821696 hasConcept C54355233 @default.
- W2023821696 hasConcept C55493867 @default.
- W2023821696 hasConcept C556039675 @default.
- W2023821696 hasConcept C71924100 @default.
- W2023821696 hasConcept C71928629 @default.
- W2023821696 hasConcept C86803240 @default.
- W2023821696 hasConcept C89423630 @default.
- W2023821696 hasConcept C98274493 @default.
- W2023821696 hasConcept C98319499 @default.
- W2023821696 hasConceptScore W2023821696C136764020 @default.
- W2023821696 hasConceptScore W2023821696C185592680 @default.
- W2023821696 hasConceptScore W2023821696C202751555 @default.
- W2023821696 hasConceptScore W2023821696C203014093 @default.
- W2023821696 hasConceptScore W2023821696C2776555147 @default.
- W2023821696 hasConceptScore W2023821696C2776635100 @default.
- W2023821696 hasConceptScore W2023821696C2778265057 @default.
- W2023821696 hasConceptScore W2023821696C2781092759 @default.
- W2023821696 hasConceptScore W2023821696C41008148 @default.
- W2023821696 hasConceptScore W2023821696C523546767 @default.
- W2023821696 hasConceptScore W2023821696C54355233 @default.
- W2023821696 hasConceptScore W2023821696C55493867 @default.
- W2023821696 hasConceptScore W2023821696C556039675 @default.
- W2023821696 hasConceptScore W2023821696C71924100 @default.
- W2023821696 hasConceptScore W2023821696C71928629 @default.
- W2023821696 hasConceptScore W2023821696C86803240 @default.
- W2023821696 hasConceptScore W2023821696C89423630 @default.
- W2023821696 hasConceptScore W2023821696C98274493 @default.
- W2023821696 hasConceptScore W2023821696C98319499 @default.
- W2023821696 hasIssue "09" @default.
- W2023821696 hasLocation W20238216961 @default.
- W2023821696 hasOpenAccess W2023821696 @default.
- W2023821696 hasPrimaryLocation W20238216961 @default.
- W2023821696 hasRelatedWork W1972454457 @default.
- W2023821696 hasRelatedWork W2018076467 @default.
- W2023821696 hasRelatedWork W2039215936 @default.
- W2023821696 hasRelatedWork W2120307572 @default.
- W2023821696 hasRelatedWork W2122101448 @default.
- W2023821696 hasRelatedWork W2265183719 @default.
- W2023821696 hasRelatedWork W2319885704 @default.
- W2023821696 hasRelatedWork W2337054254 @default.
- W2023821696 hasRelatedWork W2966602462 @default.
- W2023821696 hasRelatedWork W3096182894 @default.
- W2023821696 hasVolume "74" @default.
- W2023821696 isParatext "false" @default.
- W2023821696 isRetracted "false" @default.
- W2023821696 magId "2023821696" @default.
- W2023821696 workType "article" @default.