FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023831713> ?p ?o ?g. }

• W2023831713 endingPage "393" @default.
• W2023831713 startingPage "383" @default.
• W2023831713 abstract "This is the first US study to evaluate the clinical efficacy of acamprosate (Campral), a newly FDA-approved medication for maintaining abstinence in patients with alcohol dependence following alcohol withdrawal. We compared effects of the standard 2 g dose (n = 258) and an exploratory 3 g dose of acamprosate (n = 83) versus placebo (n = 260), and evaluated drug safety in a double-blind, placebo-controlled 6-month trial conducted in 21 outpatient clinics across the US. Participants were 601 volunteers with current alcohol dependence recruited primarily by advertisement. All patients concomitantly received eight sessions of brief manual-guided counseling (www.alcoholfree.info). The main outcome measure was the percentage of alcohol-free days over the 6-month study. Self-report was validated by breath alcohol concentration, γ-glutamyltransferase (GGT) and collateral informant interviews. The percentage of abstinent days did not differ significantly across groups in a priori analysis (54.3% for placebo, 56.1% for 2 g, 60.7% for 3 g). Post-hoc analysis controlling for baseline variables and treatment exposure found acamprosate was associated with a significantly higher percentage of abstinent days than placebo (52.3% for placebo, 58.2% for 2 g, 62.7% for 3 g; P = 0.01), with an even greater effect in the subgroup of 241 patients having a baseline goal of abstinence (58.1% for placebo, 70.0% for 2 g, 72.5% for 3 g; P = 0.02). There were no deaths or serious drug-related adverse events. The US study findings suggest that acamprosate is safe and well tolerated in a broadly inclusive sample of alcoholics and appears effective in populations of patients motivated to have a treatment goal of abstinence." @default.
• W2023831713 created "2016-06-24" @default.
• W2023831713 creator A5006907044 @default.
• W2023831713 creator A5014266793 @default.
• W2023831713 creator A5015598472 @default.
• W2023831713 creator A5029497836 @default.
• W2023831713 date "2006-08-01" @default.
• W2023831713 modified "2023-10-17" @default.
• W2023831713 title "Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: The role of patient motivation" @default.
• W2023831713 cites W1268369627 @default.
• W2023831713 cites W1769250030 @default.
• W2023831713 cites W1812217105 @default.
• W2023831713 cites W1871913730 @default.
• W2023831713 cites W1939011264 @default.
• W2023831713 cites W1965171919 @default.
• W2023831713 cites W1970343218 @default.
• W2023831713 cites W1972306082 @default.
• W2023831713 cites W1976153901 @default.
• W2023831713 cites W2006777595 @default.
• W2023831713 cites W2012140006 @default.
• W2023831713 cites W2016081949 @default.
• W2023831713 cites W2017819433 @default.
• W2023831713 cites W2027462039 @default.
• W2023831713 cites W2033122986 @default.
• W2023831713 cites W2033574236 @default.
• W2023831713 cites W2044277361 @default.
• W2023831713 cites W2056797993 @default.
• W2023831713 cites W2057415848 @default.
• W2023831713 cites W2059336065 @default.
• W2023831713 cites W2062139611 @default.
• W2023831713 cites W2063305190 @default.
• W2023831713 cites W2073941749 @default.
• W2023831713 cites W2074075381 @default.
• W2023831713 cites W20819629 @default.
• W2023831713 cites W2086688197 @default.
• W2023831713 cites W2086730289 @default.
• W2023831713 cites W2089237550 @default.
• W2023831713 cites W2093559862 @default.
• W2023831713 cites W2094419105 @default.
• W2023831713 cites W2095419965 @default.
• W2023831713 cites W2095902274 @default.
• W2023831713 cites W2097823641 @default.
• W2023831713 cites W2098785223 @default.
• W2023831713 cites W2099195029 @default.
• W2023831713 cites W2099737019 @default.
• W2023831713 cites W2104538950 @default.
• W2023831713 cites W2107031757 @default.
• W2023831713 cites W2107117723 @default.
• W2023831713 cites W2114275702 @default.
• W2023831713 cites W2115337168 @default.
• W2023831713 cites W2118061336 @default.
• W2023831713 cites W2136699488 @default.
• W2023831713 cites W2153630622 @default.
• W2023831713 cites W2157113531 @default.
• W2023831713 cites W2158472438 @default.
• W2023831713 cites W2162337181 @default.
• W2023831713 cites W2207631275 @default.
• W2023831713 cites W2275832530 @default.
• W2023831713 cites W2328373544 @default.
• W2023831713 cites W2402729458 @default.
• W2023831713 cites W2493252064 @default.
• W2023831713 cites W3090293687 @default.
• W2023831713 cites W3215125900 @default.
• W2023831713 cites W2296042795 @default.
• W2023831713 cites W2472726161 @default.
• W2023831713 doi "https://doi.org/10.1016/j.jpsychires.2006.02.002" @default.
• W2023831713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16546214" @default.
• W2023831713 hasPublicationYear "2006" @default.
• W2023831713 type Work @default.
• W2023831713 sameAs 2023831713 @default.
• W2023831713 citedByCount "189" @default.
• W2023831713 countsByYear W20238317132012 @default.
• W2023831713 countsByYear W20238317132013 @default.
• W2023831713 countsByYear W20238317132014 @default.
• W2023831713 countsByYear W20238317132015 @default.
• W2023831713 countsByYear W20238317132016 @default.
• W2023831713 countsByYear W20238317132017 @default.
• W2023831713 countsByYear W20238317132018 @default.
• W2023831713 countsByYear W20238317132019 @default.
• W2023831713 countsByYear W20238317132020 @default.
• W2023831713 countsByYear W20238317132021 @default.
• W2023831713 countsByYear W20238317132022 @default.
• W2023831713 countsByYear W20238317132023 @default.
• W2023831713 crossrefType "journal-article" @default.
• W2023831713 hasAuthorship W2023831713A5006907044 @default.
• W2023831713 hasAuthorship W2023831713A5014266793 @default.
• W2023831713 hasAuthorship W2023831713A5015598472 @default.
• W2023831713 hasAuthorship W2023831713A5029497836 @default.
• W2023831713 hasConcept C118552586 @default.
• W2023831713 hasConcept C126322002 @default.
• W2023831713 hasConcept C142724271 @default.
• W2023831713 hasConcept C15744967 @default.
• W2023831713 hasConcept C170493617 @default.
• W2023831713 hasConcept C185592680 @default.
• W2023831713 hasConcept C197934379 @default.
• W2023831713 hasConcept C204787440 @default.
• W2023831713 hasConcept C27081682 @default.
• W2023831713 hasConcept C2777972943 @default.

• next