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• W2023838079 startingPage "177" @default.
• W2023838079 abstract "Abstract Progressive supranuclear palsy (PSP) is a complex tauopathy usually confirmed at post‐mortem in advanced stages of the disease. Early PSP‐like changes that may outline the course of the disease are not known. Since PSP is not rarely associated with argyrophilic grain disease (AGD) of varible intensity, the present study was focused on AGD cases with associated PSP‐like changes in an attempt to delineate early PSP‐like pathology in this category of cases. Three were typical clinical and pathological PSP. Another case presented with cognitive impairment, abnormal behavior and two falls in the last three months. One case suffered from mild cognitive impairment, and two had no evidence of neurological abnormality. Neuropathological study revealed, in addition to AGD, increased intensity and extent of lesion in three groups of regions, striatum, pallidus/subthalamus and selected nuclei of the brain stem, correlating with neurological impairment. Biochemical studies disclosed oxidative damage in the striatum and amygdala. Together the present observations suggest (i) early PSP‐like lesions in the striatum, followed by the globus pallidus/subthalamus and selected nuclei of the brain stem; (ii) early involvement of neurons and astrocytes, but late appearance of tufted astrocytres; and (iii) oxidative damage of glial acidic protein in the striatum." @default.
• W2023838079 created "2016-06-24" @default.
• W2023838079 creator A5010636987 @default.
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• W2023838079 date "2009-03-05" @default.
• W2023838079 modified "2023-10-15" @default.
• W2023838079 title "Delineation of Early Changes in Cases with Progressive Supranuclear Palsy‐Like Pathology. Astrocytes in Striatum are Primary Targets of Tau Phosphorylation and GFAP Oxidation" @default.
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• W2023838079 doi "https://doi.org/10.1111/j.1750-3639.2008.00173.x" @default.
• W2023838079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8094872" @default.
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