FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023839991> ?p ?o ?g. }

• W2023839991 endingPage "89" @default.
• W2023839991 startingPage "85" @default.
• W2023839991 abstract "<i>Background/Aims:</i> Both the dopamine receptor D₁ agonist SKF 38393 and the antagonist SCH 23390 are benzazepine derivatives that have been widely used as pharmacological tools and radioligands. Evidence suggests that behavioral effects of both compounds do not always correspond to their established receptor subtype selectivity. Here, we assessed the effects of SKF 38393 and SCH 23390 on the synaptosomal uptake of tritiated serotonin. <i>Methods:</i> Uptake experiments were performed by using [³H]serotonin and synaptosomal fractions prepared from the hypothalamus of rat brain. <i>Results:</i> Both SKF 38393 and SCH 23390 inhibited synaptosomal uptake of [³H]serotonin, with IC₅₀ values of 910 ± 60 nmol/l and 1,400 ± 80 nmol/l, respectively. Clomipramine, a known inhibitor of serotonin uptake, and (+)-amphetamine, a weak inhibitor, had IC₅₀ values of 14 ± 1 nmol/l and more than 10,000 nmol/l, respectively, under the same experimental conditions. The IC₅₀ values for SKF 38393 and SCH 23390 fall within the broad range of corresponding values for antidepressants that have been shown to inhibit the uptake of serotonin. This finding indicates that SKF 38393 and SCH 23390 can enhance the activity of the serotonergic system in the brain, a mechanism that may be responsible for some of the effects of these drugs. <i>Conclusion:</i> SKF 38393 and SCH 23390 are useful tools to differentiate D₁ from D₂ receptors, but their indirect effects on serotonergic mechanisms have to be considered." @default.
• W2023839991 created "2016-06-24" @default.
• W2023839991 creator A5016888266 @default.
• W2023839991 creator A5037319115 @default.
• W2023839991 creator A5066247901 @default.
• W2023839991 creator A5081661174 @default.
• W2023839991 date "2011-01-01" @default.
• W2023839991 modified "2023-09-27" @default.
• W2023839991 title "SKF 38393 and SCH 23390 Inhibit Reuptake of Serotonin by Rat Hypothalamic Synaptosomes" @default.
• W2023839991 cites W1895729847 @default.
• W2023839991 cites W1964202864 @default.
• W2023839991 cites W1976651077 @default.
• W2023839991 cites W1979293025 @default.
• W2023839991 cites W1980411146 @default.
• W2023839991 cites W1988619576 @default.
• W2023839991 cites W1990199636 @default.
• W2023839991 cites W1993905365 @default.
• W2023839991 cites W1994094794 @default.
• W2023839991 cites W1995244999 @default.
• W2023839991 cites W1998632384 @default.
• W2023839991 cites W2004781213 @default.
• W2023839991 cites W2014200747 @default.
• W2023839991 cites W2016264491 @default.
• W2023839991 cites W2019508995 @default.
• W2023839991 cites W2023733028 @default.
• W2023839991 cites W2023770577 @default.
• W2023839991 cites W2026883305 @default.
• W2023839991 cites W2034253843 @default.
• W2023839991 cites W2040479688 @default.
• W2023839991 cites W2040906507 @default.
• W2023839991 cites W2046515704 @default.
• W2023839991 cites W2050580902 @default.
• W2023839991 cites W2053700326 @default.
• W2023839991 cites W2055953604 @default.
• W2023839991 cites W2057304728 @default.
• W2023839991 cites W2060746641 @default.
• W2023839991 cites W2071403847 @default.
• W2023839991 cites W2074420561 @default.
• W2023839991 cites W2083605770 @default.
• W2023839991 cites W2084530213 @default.
• W2023839991 cites W2086013684 @default.
• W2023839991 cites W2093220261 @default.
• W2023839991 cites W2093708977 @default.
• W2023839991 cites W2097871535 @default.
• W2023839991 cites W2113485191 @default.
• W2023839991 cites W2127514796 @default.
• W2023839991 cites W2135994260 @default.
• W2023839991 cites W2150205846 @default.
• W2023839991 cites W2154753677 @default.
• W2023839991 cites W2159899816 @default.
• W2023839991 cites W2176224597 @default.
• W2023839991 cites W2200434255 @default.
• W2023839991 cites W2072301812 @default.
• W2023839991 doi "https://doi.org/10.1159/000323232" @default.
• W2023839991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21242715" @default.
• W2023839991 hasPublicationYear "2011" @default.
• W2023839991 type Work @default.
• W2023839991 sameAs 2023839991 @default.
• W2023839991 citedByCount "11" @default.
• W2023839991 countsByYear W20238399912012 @default.
• W2023839991 countsByYear W20238399912014 @default.
• W2023839991 countsByYear W20238399912015 @default.
• W2023839991 countsByYear W20238399912017 @default.
• W2023839991 countsByYear W20238399912019 @default.
• W2023839991 countsByYear W20238399912022 @default.
• W2023839991 crossrefType "journal-article" @default.
• W2023839991 hasAuthorship W2023839991A5016888266 @default.
• W2023839991 hasAuthorship W2023839991A5037319115 @default.
• W2023839991 hasAuthorship W2023839991A5066247901 @default.
• W2023839991 hasAuthorship W2023839991A5081661174 @default.
• W2023839991 hasConcept C126322002 @default.
• W2023839991 hasConcept C134018914 @default.
• W2023839991 hasConcept C170493617 @default.
• W2023839991 hasConcept C185592680 @default.
• W2023839991 hasConcept C2775864247 @default.
• W2023839991 hasConcept C2776885963 @default.
• W2023839991 hasConcept C2778938600 @default.
• W2023839991 hasConcept C2779917531 @default.
• W2023839991 hasConcept C37000724 @default.
• W2023839991 hasConcept C55493867 @default.
• W2023839991 hasConcept C58732023 @default.
• W2023839991 hasConcept C71924100 @default.
• W2023839991 hasConcept C86803240 @default.
• W2023839991 hasConcept C98274493 @default.
• W2023839991 hasConceptScore W2023839991C126322002 @default.
• W2023839991 hasConceptScore W2023839991C134018914 @default.
• W2023839991 hasConceptScore W2023839991C170493617 @default.
• W2023839991 hasConceptScore W2023839991C185592680 @default.
• W2023839991 hasConceptScore W2023839991C2775864247 @default.
• W2023839991 hasConceptScore W2023839991C2776885963 @default.
• W2023839991 hasConceptScore W2023839991C2778938600 @default.
• W2023839991 hasConceptScore W2023839991C2779917531 @default.
• W2023839991 hasConceptScore W2023839991C37000724 @default.
• W2023839991 hasConceptScore W2023839991C55493867 @default.
• W2023839991 hasConceptScore W2023839991C58732023 @default.
• W2023839991 hasConceptScore W2023839991C71924100 @default.
• W2023839991 hasConceptScore W2023839991C86803240 @default.
• W2023839991 hasConceptScore W2023839991C98274493 @default.

• next