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- W2023840135 abstract "Cis-dichloro(1,3-diamino-2-propanol)palladium(II), cis-[Pd(dapol)Cl2], reacts with stoichiometric amounts of AgClO4 to give chloride free solutions of cis-[Pd(dapol)(H20)2](ClO4)2 (compound 1). Twelve mixed compound I/acetic acid (AcOH) solutions having three different I/AcOH molar ratios and/or total molar complex concentration have been titrated with NaOH 0.1 mol dm−3 at 37°C and I = 0.15 mol dm−3 (NaClO4). Formation constants (log βpqr) of mixed hydroxoacetato complexes were fitted for the equilibrium: pPdL(H2O)2 + gAcO − rH ⇄ (PdL)p (AcO)q (H2O)2-r (OH)r using the log β of acetate ion protonation (also determined) and the corresponding log βpqr data for aqua- and/or hydroxo-complexes previously reported (as fixed values). New calculations were performed by the HYPERQUAD program. Simulated and experimental titrations agree well. Several distribution diagrams are used to show that acetate ions prevent the alkaline hydrolysis of compound I to a lesser extent than they do chloride ions. Both chloride and acetate ions could compete but also contribute to preventing such hydrolysis in weakly acid or nearly neutral solutions. These findings also apply inside cells at physiological conditions (pH = 7.2–7.4 and [Cl−] ∼4 mM) for a total molar complex concentration of ∼1 mM in which compound I could react with DNA and related biopolymers @ 1998 Elsevier Science B.V All rights reserved." @default.
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- W2023840135 date "1998-05-01" @default.
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- W2023840135 title "Coordinating ability of the acetate ion towards cis-(1,3-diamine-2-hydroxypropane)palladium(II) chelate units in aqueous solutions. Preliminary study about the possibility of the acetato ligand to be involved in complex formation equilibria with palladium(II)-based anticancer drugs" @default.
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- W2023840135 doi "https://doi.org/10.1016/s1381-5148(97)00101-6" @default.
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