Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023841178> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2023841178 endingPage "908" @default.
- W2023841178 startingPage "905" @default.
- W2023841178 abstract "The aim of the present study was to delay the release of chloroquine to distal parts of the gastrointestinal tract by using a multiparticulate hydrogel formulation. Amidated pectin chloroquine beads (PC) with varying pectin-to-chloroquine ratios (PC) w/w loadings of 4:1, 2:1, and 1:1 in the dried beads were prepared by the gelation of drug-loaded pectin solutions in the presence of calcium. In vitro release studies of chloroquine from pectin-chloroquine hydrogel beads and chloroquine diphosphate powder were carried out in simulated gastric and intestinal fluids. The total release of the entrapped chloroquine from the hydrogel beads was achieved between 4 and 7 h in simulated intestinal fluid, but total release was not achieved in simulated gastric fluid. However, total release from chloroquine diphosphate powder was achieved by 1.5 and 2 h in gastric and intestinal fluids, respectively. The plasma pharmacokinetics of chloroquine from pectin hydrogel beads and chloroquine diphosphate solution following single or repeated dosing were compared in male Sprague-Dawley rats over a period of 60 h. Oral administration of the hyrogel beads to rats produced maximum plasma concentrations by 7 h, but highest plasma concentrations following chloroquine solution administration were observed by 2 h. The dissolution data and appearance of significant plasma concentrations of chloroquine 2 to 4 h after oral administration suggests release in duodenum, jejunum, or ileum." @default.
- W2023841178 created "2016-06-24" @default.
- W2023841178 creator A5010644486 @default.
- W2023841178 creator A5025564175 @default.
- W2023841178 creator A5079662738 @default.
- W2023841178 creator A5088776004 @default.
- W2023841178 date "1998-08-01" @default.
- W2023841178 modified "2023-10-16" @default.
- W2023841178 title "An Investigation into the Suitability of Amidated Pectin Hydrogel Beads as a Delivery Matrix for Chloroquine" @default.
- W2023841178 cites W126201954 @default.
- W2023841178 cites W1972613476 @default.
- W2023841178 cites W1993255059 @default.
- W2023841178 cites W1994947810 @default.
- W2023841178 cites W2009008364 @default.
- W2023841178 cites W2035371366 @default.
- W2023841178 cites W2043606915 @default.
- W2023841178 cites W2087304276 @default.
- W2023841178 cites W2088485169 @default.
- W2023841178 cites W2152912596 @default.
- W2023841178 cites W2405695921 @default.
- W2023841178 doi "https://doi.org/10.1021/js9801283" @default.
- W2023841178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9687331" @default.
- W2023841178 hasPublicationYear "1998" @default.
- W2023841178 type Work @default.
- W2023841178 sameAs 2023841178 @default.
- W2023841178 citedByCount "29" @default.
- W2023841178 countsByYear W20238411782013 @default.
- W2023841178 countsByYear W20238411782014 @default.
- W2023841178 countsByYear W20238411782016 @default.
- W2023841178 countsByYear W20238411782019 @default.
- W2023841178 countsByYear W20238411782021 @default.
- W2023841178 countsByYear W20238411782022 @default.
- W2023841178 countsByYear W20238411782023 @default.
- W2023841178 crossrefType "journal-article" @default.
- W2023841178 hasAuthorship W2023841178A5010644486 @default.
- W2023841178 hasAuthorship W2023841178A5025564175 @default.
- W2023841178 hasAuthorship W2023841178A5079662738 @default.
- W2023841178 hasAuthorship W2023841178A5088776004 @default.
- W2023841178 hasConcept C112705442 @default.
- W2023841178 hasConcept C185592680 @default.
- W2023841178 hasConcept C202751555 @default.
- W2023841178 hasConcept C203014093 @default.
- W2023841178 hasConcept C2776366702 @default.
- W2023841178 hasConcept C2777056448 @default.
- W2023841178 hasConcept C2777425658 @default.
- W2023841178 hasConcept C2778048844 @default.
- W2023841178 hasConcept C2780756937 @default.
- W2023841178 hasConcept C43617362 @default.
- W2023841178 hasConcept C55493867 @default.
- W2023841178 hasConcept C71924100 @default.
- W2023841178 hasConcept C77281830 @default.
- W2023841178 hasConcept C98274493 @default.
- W2023841178 hasConceptScore W2023841178C112705442 @default.
- W2023841178 hasConceptScore W2023841178C185592680 @default.
- W2023841178 hasConceptScore W2023841178C202751555 @default.
- W2023841178 hasConceptScore W2023841178C203014093 @default.
- W2023841178 hasConceptScore W2023841178C2776366702 @default.
- W2023841178 hasConceptScore W2023841178C2777056448 @default.
- W2023841178 hasConceptScore W2023841178C2777425658 @default.
- W2023841178 hasConceptScore W2023841178C2778048844 @default.
- W2023841178 hasConceptScore W2023841178C2780756937 @default.
- W2023841178 hasConceptScore W2023841178C43617362 @default.
- W2023841178 hasConceptScore W2023841178C55493867 @default.
- W2023841178 hasConceptScore W2023841178C71924100 @default.
- W2023841178 hasConceptScore W2023841178C77281830 @default.
- W2023841178 hasConceptScore W2023841178C98274493 @default.
- W2023841178 hasIssue "8" @default.
- W2023841178 hasLocation W20238411781 @default.
- W2023841178 hasLocation W20238411782 @default.
- W2023841178 hasOpenAccess W2023841178 @default.
- W2023841178 hasPrimaryLocation W20238411781 @default.
- W2023841178 hasRelatedWork W1517642729 @default.
- W2023841178 hasRelatedWork W1810968242 @default.
- W2023841178 hasRelatedWork W1973315847 @default.
- W2023841178 hasRelatedWork W1979331942 @default.
- W2023841178 hasRelatedWork W2023284629 @default.
- W2023841178 hasRelatedWork W273211323 @default.
- W2023841178 hasRelatedWork W3162173485 @default.
- W2023841178 hasRelatedWork W4379211442 @default.
- W2023841178 hasRelatedWork W192007196 @default.
- W2023841178 hasRelatedWork W2484300805 @default.
- W2023841178 hasVolume "87" @default.
- W2023841178 isParatext "false" @default.
- W2023841178 isRetracted "false" @default.
- W2023841178 magId "2023841178" @default.
- W2023841178 workType "article" @default.