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- W2023841187 abstract "Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, is a complex multifactorial disease characterized by metabolic deregulations that include accumulation of lipids in the liver, lipotoxicity, and insulin resistance. The progression of NAFLD to non-alcoholic steatohepatitis and cirrhosis, and ultimately to carcinomas, is governed by interplay of pro-inflammatory pathways, oxidative stress, as well as fibrogenic and apoptotic cues. As the liver is the major organ of biotransformation, deregulations in hepatic signaling pathways have effects on both, xenobiotic and endobiotic metabolism. Several major nuclear receptors involved in the transcription and regulation of phase I and II drug metabolizing enzymes and transporters also have endobiotic ligands including several lipids. Hence, hepatic lipid accumulation in steatosis and NAFLD, which leads to deregulated activation patterns of nuclear receptors, may result in altered drug metabolism capacity in NAFLD patients. On the other hand, genetic and association studies have indicated that a malfunction in drug metabolism can affect the prevalence and severity of NAFLD. This review focuses on the complex interplay between NAFLD pathogenesis and drug metabolism. A better understanding of these relationships is a prerequisite for developing improved drug dosing algorithms for the pharmacotherapy of patients with different stages of NAFLD." @default.
- W2023841187 created "2016-06-24" @default.
- W2023841187 creator A5012297491 @default.
- W2023841187 creator A5018486258 @default.
- W2023841187 creator A5044688765 @default.
- W2023841187 date "2013-01-01" @default.
- W2023841187 modified "2023-10-14" @default.
- W2023841187 title "Molecular Interactions between NAFLD and Xenobiotic Metabolism" @default.
- W2023841187 cites W137548726 @default.
- W2023841187 cites W1574217570 @default.
- W2023841187 cites W1622799587 @default.
- W2023841187 cites W1963533730 @default.
- W2023841187 cites W1963683487 @default.
- W2023841187 cites W1964775061 @default.
- W2023841187 cites W1966052494 @default.
- W2023841187 cites W1967140028 @default.
- W2023841187 cites W1969149505 @default.
- W2023841187 cites W1971042451 @default.
- W2023841187 cites W1972127709 @default.
- W2023841187 cites W1972709924 @default.
- W2023841187 cites W1972996926 @default.
- W2023841187 cites W1973243569 @default.
- W2023841187 cites W1974436444 @default.
- W2023841187 cites W1974658675 @default.
- W2023841187 cites W1974744093 @default.
- W2023841187 cites W1976621212 @default.
- W2023841187 cites W1978160817 @default.
- W2023841187 cites W1978274444 @default.
- W2023841187 cites W1981146067 @default.
- W2023841187 cites W1982237658 @default.
- W2023841187 cites W1983773316 @default.
- W2023841187 cites W1984077928 @default.
- W2023841187 cites W1984534635 @default.
- W2023841187 cites W1984906923 @default.
- W2023841187 cites W1985236262 @default.
- W2023841187 cites W1985592156 @default.
- W2023841187 cites W1986864047 @default.
- W2023841187 cites W1986918553 @default.
- W2023841187 cites W1990041972 @default.
- W2023841187 cites W1990055069 @default.
- W2023841187 cites W1990640778 @default.
- W2023841187 cites W1990819179 @default.
- W2023841187 cites W1990986870 @default.
- W2023841187 cites W1991095764 @default.
- W2023841187 cites W1992127373 @default.
- W2023841187 cites W1992871875 @default.
- W2023841187 cites W1993375122 @default.
- W2023841187 cites W1993742578 @default.
- W2023841187 cites W1994834284 @default.
- W2023841187 cites W1997532751 @default.
- W2023841187 cites W1997538585 @default.
- W2023841187 cites W2000129233 @default.
- W2023841187 cites W2000545769 @default.
- W2023841187 cites W2002531805 @default.
- W2023841187 cites W2003626278 @default.
- W2023841187 cites W2007887164 @default.
- W2023841187 cites W2008169198 @default.
- W2023841187 cites W2008825225 @default.
- W2023841187 cites W2009838390 @default.
- W2023841187 cites W2010101404 @default.
- W2023841187 cites W2010340961 @default.
- W2023841187 cites W2012528744 @default.
- W2023841187 cites W2014534600 @default.
- W2023841187 cites W2015711200 @default.
- W2023841187 cites W2016507966 @default.
- W2023841187 cites W2021139519 @default.
- W2023841187 cites W2026160870 @default.
- W2023841187 cites W2027391841 @default.
- W2023841187 cites W2031155689 @default.
- W2023841187 cites W2032038009 @default.
- W2023841187 cites W2032129662 @default.
- W2023841187 cites W2033957878 @default.
- W2023841187 cites W2034298464 @default.
- W2023841187 cites W2035262830 @default.
- W2023841187 cites W2036041153 @default.
- W2023841187 cites W2038238538 @default.
- W2023841187 cites W2040012853 @default.
- W2023841187 cites W2044311796 @default.
- W2023841187 cites W2047410156 @default.
- W2023841187 cites W2048397414 @default.
- W2023841187 cites W2049481936 @default.
- W2023841187 cites W2053026149 @default.
- W2023841187 cites W2053186448 @default.
- W2023841187 cites W2054557659 @default.
- W2023841187 cites W2055606723 @default.
- W2023841187 cites W2058709707 @default.
- W2023841187 cites W2059415816 @default.
- W2023841187 cites W2060802146 @default.
- W2023841187 cites W2061725840 @default.
- W2023841187 cites W2062009438 @default.
- W2023841187 cites W2065612971 @default.
- W2023841187 cites W2065880243 @default.
- W2023841187 cites W2070055730 @default.
- W2023841187 cites W2070391921 @default.
- W2023841187 cites W2073438076 @default.
- W2023841187 cites W2076249810 @default.
- W2023841187 cites W2076793953 @default.
- W2023841187 cites W2077678888 @default.
- W2023841187 cites W2078176020 @default.
- W2023841187 cites W2080228333 @default.