FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023843484> ?p ?o ?g. }

• W2023843484 endingPage "985" @default.
• W2023843484 startingPage "973" @default.
• W2023843484 abstract "RNA interference (RNAi)-based therapeutics have the potential to treat chronic hepatitis B virus (HBV) infection in a fundamentally different manner than current therapies. Using RNAi, it is possible to knock down expression of viral RNAs including the pregenomic RNA from which the replicative intermediates are derived, thus reducing viral load, and the viral proteins that result in disease and impact the immune system's ability to eliminate the virus. We previously described the use of polymer-based Dynamic PolyConjugate (DPC) for the targeted delivery of siRNAs to hepatocytes. Here, we first show in proof-of-concept studies that simple coinjection of a hepatocyte-targeted, N-acetylgalactosamine-conjugated melittin-like peptide (NAG-MLP) with a liver-tropic cholesterol-conjugated siRNA (chol-siRNA) targeting coagulation factor VII (F7) results in efficient F7 knockdown in mice and nonhuman primates without changes in clinical chemistry or induction of cytokines. Using transient and transgenic mouse models of HBV infection, we show that a single coinjection of NAG-MLP with potent chol-siRNAs targeting conserved HBV sequences resulted in multilog repression of viral RNA, proteins, and viral DNA with long duration of effect. These results suggest that coinjection of NAG-MLP and chol-siHBVs holds great promise as a new therapeutic for patients chronically infected with HBV." @default.
• W2023843484 created "2016-06-24" @default.
• W2023843484 creator A5006873736 @default.
• W2023843484 creator A5008070107 @default.
• W2023843484 creator A5014112650 @default.
• W2023843484 creator A5016841209 @default.
• W2023843484 creator A5024537506 @default.
• W2023843484 creator A5026620431 @default.
• W2023843484 creator A5037603097 @default.
• W2023843484 creator A5038429896 @default.
• W2023843484 creator A5047840131 @default.
• W2023843484 creator A5058407001 @default.
• W2023843484 creator A5064786045 @default.
• W2023843484 creator A5069815769 @default.
• W2023843484 creator A5076865852 @default.
• W2023843484 creator A5079818556 @default.
• W2023843484 creator A5082542863 @default.
• W2023843484 creator A5091145034 @default.
• W2023843484 creator A5079853917 @default.
• W2023843484 date "2013-05-01" @default.
• W2023843484 modified "2023-10-16" @default.
• W2023843484 title "Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection" @default.
• W2023843484 cites W1502826501 @default.
• W2023843484 cites W1513593427 @default.
• W2023843484 cites W1544473294 @default.
• W2023843484 cites W1552117346 @default.
• W2023843484 cites W1675450733 @default.
• W2023843484 cites W1845254015 @default.
• W2023843484 cites W1912024884 @default.
• W2023843484 cites W1937979429 @default.
• W2023843484 cites W1968829868 @default.
• W2023843484 cites W1985505095 @default.
• W2023843484 cites W1986655312 @default.
• W2023843484 cites W1997681955 @default.
• W2023843484 cites W2001609707 @default.
• W2023843484 cites W2009509017 @default.
• W2023843484 cites W2011090644 @default.
• W2023843484 cites W2019631541 @default.
• W2023843484 cites W2029271422 @default.
• W2023843484 cites W2029653860 @default.
• W2023843484 cites W2031174462 @default.
• W2023843484 cites W2036402301 @default.
• W2023843484 cites W2037402545 @default.
• W2023843484 cites W2040799770 @default.
• W2023843484 cites W2048369172 @default.
• W2023843484 cites W2070889557 @default.
• W2023843484 cites W2071930289 @default.
• W2023843484 cites W2077680450 @default.
• W2023843484 cites W2082534929 @default.
• W2023843484 cites W2086342653 @default.
• W2023843484 cites W2101273158 @default.
• W2023843484 cites W2102068103 @default.
• W2023843484 cites W2102766721 @default.
• W2023843484 cites W2103793964 @default.
• W2023843484 cites W2105550963 @default.
• W2023843484 cites W2107277218 @default.
• W2023843484 cites W2113597524 @default.
• W2023843484 cites W2116424844 @default.
• W2023843484 cites W2121914083 @default.
• W2023843484 cites W2133291642 @default.
• W2023843484 cites W2134066410 @default.
• W2023843484 cites W2143313350 @default.
• W2023843484 cites W2147155982 @default.
• W2023843484 cites W2150001528 @default.
• W2023843484 cites W2154097176 @default.
• W2023843484 cites W2161582292 @default.
• W2023843484 cites W2172643117 @default.
• W2023843484 cites W2175117246 @default.
• W2023843484 cites W4294216491 @default.
• W2023843484 doi "https://doi.org/10.1038/mt.2013.31" @default.
• W2023843484 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3666629" @default.
• W2023843484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23439496" @default.
• W2023843484 hasPublicationYear "2013" @default.
• W2023843484 type Work @default.
• W2023843484 sameAs 2023843484 @default.
• W2023843484 citedByCount "255" @default.
• W2023843484 countsByYear W20238434842013 @default.
• W2023843484 countsByYear W20238434842014 @default.
• W2023843484 countsByYear W20238434842015 @default.
• W2023843484 countsByYear W20238434842016 @default.
• W2023843484 countsByYear W20238434842017 @default.
• W2023843484 countsByYear W20238434842018 @default.
• W2023843484 countsByYear W20238434842019 @default.
• W2023843484 countsByYear W20238434842020 @default.
• W2023843484 countsByYear W20238434842021 @default.
• W2023843484 countsByYear W20238434842022 @default.
• W2023843484 countsByYear W20238434842023 @default.
• W2023843484 crossrefType "journal-article" @default.
• W2023843484 hasAuthorship W2023843484A5006873736 @default.
• W2023843484 hasAuthorship W2023843484A5008070107 @default.
• W2023843484 hasAuthorship W2023843484A5014112650 @default.
• W2023843484 hasAuthorship W2023843484A5016841209 @default.
• W2023843484 hasAuthorship W2023843484A5024537506 @default.
• W2023843484 hasAuthorship W2023843484A5026620431 @default.
• W2023843484 hasAuthorship W2023843484A5037603097 @default.
• W2023843484 hasAuthorship W2023843484A5038429896 @default.
• W2023843484 hasAuthorship W2023843484A5047840131 @default.
• W2023843484 hasAuthorship W2023843484A5058407001 @default.

• next