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- W2023843575 abstract "RS-2135 is the (+) isomer of a novel, fused carbazol derivative. The agent, when administered orally, shows long-lasting antiarrhythmic effects in several models of arrhythmia. We used standard microelectrode techniques to characterize the electrophysiological effects of the agent on canine Purkinje fibers. RS-2135 reduced the maximum upstroke velocity of the action potential (Vmax) and shortened the action potential duration (APD) in a concentration-related manner (0.3-3 microM). RS-2135 decreased Vmax at lower concentrations than disopyramide, flecainide, and mexiletine. RS-2135 shortened the effective refractory period (ERP), but significantly increased the ratio of ERP to APD90. Additionally, the effects of the (-) optical isomer of RS-2135 were compared with those of RS-2135, the (+) enantiomer. The (-) isomer was much less potent than RS-2135 in decreasing Vmax. These data suggest that RS-2135 belongs to the class I or local anesthetic type of antiarrhythmic agent and that the stereochemistry of the drug molecule is an important determinant of Na channel blocking activity." @default.
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- W2023843575 date "1992-12-01" @default.
- W2023843575 modified "2023-09-25" @default.
- W2023843575 title "Electrophysiologic Effects of RS-2135, a New Antiarrhythmic Compound, on Canine Purkinje Fibers" @default.
- W2023843575 doi "https://doi.org/10.1097/00005344-199212000-00016" @default.
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