FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023843842> ?p ?o ?g. }

• W2023843842 endingPage "738" @default.
• W2023843842 startingPage "733" @default.
• W2023843842 abstract "Introduction. Some experimental trials have demonstrated that rapamycin (RAPA) is able to inhibit HIV-1 progression in three different ways: (1) reducing CCR5-gene transcription, (2) blocking interleukin-2 intracellular secondary messenger (mammalian target of rapamycin), and (3) up-regulating the β-chemokine macrophage inflammatory protein (MIP; MIP-1α and MIP-1β). We present the preliminary results of a prospective nonrandomized trial concerning the first HIV patient series receiving RAPA monotherapy after liver transplantation (LT). Methods. Since June 2003, 14 HIV patients have received cadaveric donor LT due to end-stage liver disease (ESLD) associated or not associated with hepatocellular carcinoma, scored by the model for ESLD system. Patients were assessed using the following criteria for HIV characterization: CD4 T-cell count more than 100/mL and HIV-RNA levels less than 50 copies/mL. Primary immunosuppression was based on calcineurin inhibitors (CI), whereas switch to RAPA monotherapy occurred in cases of CI complications or Kaposi's sarcoma. Results. Mean overall post-LT follow-up was 14.8 months (range: 0.5–52.6). Six of 14 patients were administered RAPA monotherapy. Mean preswitch period from CI to RAPA was 67 days (range: 10–225 days). Mean postswitch follow-up was 11.9 months (range: 2–31 months). All patients were affected by ESLD, which was associated with hepatocellular carcinoma in seven patients. ESLD occurred due to hepatitis C virus (HCV)-related hepatopathy for nine patients, hepatitis B virus-related hepatopathy for one patient, and hepatitis B virus-HCV hepatopathy for four patients. Significantly better control of HIV and HCV replication was found among patients taking RAPA monotherapy (P=0.0001 and 0.03, respectively). Conclusions. After in vitro and in vivo experimental evidence of RAPA antiviral proprieties, to our knowledge, this is the first clinical report of several significant benefits in long-term immunosuppression maintenance and HIV-1 control among HIV positive patients who underwent LT." @default.
• W2023843842 created "2016-06-24" @default.
• W2023843842 creator A5000883758 @default.
• W2023843842 creator A5003061042 @default.
• W2023843842 creator A5007635069 @default.
• W2023843842 creator A5015842968 @default.
• W2023843842 creator A5027690349 @default.
• W2023843842 creator A5028700932 @default.
• W2023843842 creator A5053986252 @default.
• W2023843842 creator A5054757201 @default.
• W2023843842 creator A5091501685 @default.
• W2023843842 date "2010-03-27" @default.
• W2023843842 modified "2023-09-27" @default.
• W2023843842 title "First Report on a Series of HIV Patients Undergoing Rapamycin Monotherapy After Liver Transplantation" @default.
• W2023843842 cites W1657655805 @default.
• W2023843842 cites W1966515400 @default.
• W2023843842 cites W1982867836 @default.
• W2023843842 cites W2004366555 @default.
• W2023843842 cites W2017374468 @default.
• W2023843842 cites W2021299297 @default.
• W2023843842 cites W2037246938 @default.
• W2023843842 cites W2054825291 @default.
• W2023843842 cites W2061238323 @default.
• W2023843842 cites W2062007252 @default.
• W2023843842 cites W2073586734 @default.
• W2023843842 cites W2081689384 @default.
• W2023843842 cites W2090407808 @default.
• W2023843842 cites W2090630729 @default.
• W2023843842 cites W2120356140 @default.
• W2023843842 cites W2126493366 @default.
• W2023843842 cites W2134194140 @default.
• W2023843842 cites W2145718464 @default.
• W2023843842 cites W2147855115 @default.
• W2023843842 cites W2150549563 @default.
• W2023843842 cites W2155246095 @default.
• W2023843842 cites W2166932944 @default.
• W2023843842 cites W2172227861 @default.
• W2023843842 cites W2315027248 @default.
• W2023843842 doi "https://doi.org/10.1097/tp.0b013e3181c7dcc0" @default.
• W2023843842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20048692" @default.
• W2023843842 hasPublicationYear "2010" @default.
• W2023843842 type Work @default.
• W2023843842 sameAs 2023843842 @default.
• W2023843842 citedByCount "61" @default.
• W2023843842 countsByYear W20238438422012 @default.
• W2023843842 countsByYear W20238438422013 @default.
• W2023843842 countsByYear W20238438422014 @default.
• W2023843842 countsByYear W20238438422015 @default.
• W2023843842 countsByYear W20238438422017 @default.
• W2023843842 countsByYear W20238438422018 @default.
• W2023843842 countsByYear W20238438422019 @default.
• W2023843842 countsByYear W20238438422020 @default.
• W2023843842 countsByYear W20238438422021 @default.
• W2023843842 countsByYear W20238438422022 @default.
• W2023843842 countsByYear W20238438422023 @default.
• W2023843842 crossrefType "journal-article" @default.
• W2023843842 hasAuthorship W2023843842A5000883758 @default.
• W2023843842 hasAuthorship W2023843842A5003061042 @default.
• W2023843842 hasAuthorship W2023843842A5007635069 @default.
• W2023843842 hasAuthorship W2023843842A5015842968 @default.
• W2023843842 hasAuthorship W2023843842A5027690349 @default.
• W2023843842 hasAuthorship W2023843842A5028700932 @default.
• W2023843842 hasAuthorship W2023843842A5053986252 @default.
• W2023843842 hasAuthorship W2023843842A5054757201 @default.
• W2023843842 hasAuthorship W2023843842A5091501685 @default.
• W2023843842 hasBestOaLocation W20238438421 @default.
• W2023843842 hasConcept C126322002 @default.
• W2023843842 hasConcept C128057223 @default.
• W2023843842 hasConcept C203014093 @default.
• W2023843842 hasConcept C2522874641 @default.
• W2023843842 hasConcept C2776408679 @default.
• W2023843842 hasConcept C2776455275 @default.
• W2023843842 hasConcept C2777075537 @default.
• W2023843842 hasConcept C2778019345 @default.
• W2023843842 hasConcept C2779609443 @default.
• W2023843842 hasConcept C2780252810 @default.
• W2023843842 hasConcept C2780593183 @default.
• W2023843842 hasConcept C2911091166 @default.
• W2023843842 hasConcept C71924100 @default.
• W2023843842 hasConcept C90924648 @default.
• W2023843842 hasConceptScore W2023843842C126322002 @default.
• W2023843842 hasConceptScore W2023843842C128057223 @default.
• W2023843842 hasConceptScore W2023843842C203014093 @default.
• W2023843842 hasConceptScore W2023843842C2522874641 @default.
• W2023843842 hasConceptScore W2023843842C2776408679 @default.
• W2023843842 hasConceptScore W2023843842C2776455275 @default.
• W2023843842 hasConceptScore W2023843842C2777075537 @default.
• W2023843842 hasConceptScore W2023843842C2778019345 @default.
• W2023843842 hasConceptScore W2023843842C2779609443 @default.
• W2023843842 hasConceptScore W2023843842C2780252810 @default.
• W2023843842 hasConceptScore W2023843842C2780593183 @default.
• W2023843842 hasConceptScore W2023843842C2911091166 @default.
• W2023843842 hasConceptScore W2023843842C71924100 @default.
• W2023843842 hasConceptScore W2023843842C90924648 @default.
• W2023843842 hasIssue "6" @default.
• W2023843842 hasLocation W20238438421 @default.
• W2023843842 hasLocation W20238438422 @default.
• W2023843842 hasLocation W20238438423 @default.

• next