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- W2023844039 abstract "A study is reported which compares the results of measurements of whole blood phenylalanine by the Guthrie inhibition assay with those obtained by established procedures for phenylalanine. Blood from newborn infants, from patients with treated and untreated phenylketonuria, and from animals with experimental phenylketonuria was tested. Results obtained by the inhibition assay were consistently higher than those obtained by other methods. The inhibition procedure measures substances unrelated to phenylalanine. The inhibition method, with the use of whole blood, is probably not sensitive enough for use as a test for detection of phenylketonuria in a nursery for newborn infants. A study is reported which compares the results of measurements of whole blood phenylalanine by the Guthrie inhibition assay with those obtained by established procedures for phenylalanine. Blood from newborn infants, from patients with treated and untreated phenylketonuria, and from animals with experimental phenylketonuria was tested. Results obtained by the inhibition assay were consistently higher than those obtained by other methods. The inhibition procedure measures substances unrelated to phenylalanine. The inhibition method, with the use of whole blood, is probably not sensitive enough for use as a test for detection of phenylketonuria in a nursery for newborn infants." @default.
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- W2023844039 date "1962-10-01" @default.
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- W2023844039 title "Comparison of serum phenylalanine levels with growth in Guthrie's inhibition assay in newborn infants" @default.
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- W2023844039 doi "https://doi.org/10.1016/s0022-3476(62)80155-3" @default.
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