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- W2023849298 abstract "Polyclonal antipeptide antisera have been utilized to quantitate the amount of retinal rod outer segment cGMP phosphodiesterase α and β catalytic subunits present in retinas from C57BL/6J mice which are normal or carriers for the rd gene defect. Results suggest that the quantity of PDE-β subunit is reduced in carrier mice while PDE-α and PDE-γ are not affected. In 21-day-old mice, the PDE-β was reduced by about one-half while adult carrier mice had even more reduced levels of PDE-β. Since PDEα was not reduced, this suggests that synthesis of PDEα and PDEβ may not be coordinately controlled." @default.
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- W2023849298 date "1992-04-01" @default.
- W2023849298 modified "2023-10-16" @default.
- W2023849298 title "Carriers of the mouse rd gene have reduced levels of the beta subunit of the retinal cyclic GMP phosphodiesterase" @default.
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- W2023849298 doi "https://doi.org/10.1016/0006-291x(92)91216-d" @default.
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