FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023852409> ?p ?o ?g. }

• W2023852409 endingPage "e0125116" @default.
• W2023852409 startingPage "e0125116" @default.
• W2023852409 abstract "Neurons derived from human induced pluripotent stem cells (iPSCs) represent a potentially valuable tool for the characterisation of neuronal receptors and ion channels. Previous studies on iPSC-derived neuronal cells have reported the functional characterisation of a variety of receptors and ion channels, including glutamate receptors, γ-aminobutyric acid (GABA) receptors and several voltage-gated ion channels. In the present study we have examined the expression and functional properties of nicotinic acetylcholine receptors (nAChRs) in human iPSC-derived neurons. Gene expression analysis indicated the presence of transcripts encoding several nAChR subunits, with highest levels detected for α3-α7, β1, β2 and β4 subunits (encoded by CHRNA3-CHRNA7, CHRNB1, CHRNB2 and CHRNB4 genes). In addition, similarly high transcript levels were detected for the truncated dupα7 subunit transcript, encoded by the partially duplicated gene CHRFAM7A, which has been associated with psychiatric disorders such as schizophrenia. The functional properties of these nAChRs have been examined by calcium fluorescence and by patch-clamp recordings. The data obtained suggest that the majority of functional nAChRs expressed in these cells have pharmacological properties typical of α7 receptors. Large responses were induced by a selective α7 agonist (compound B), in the presence of the α7-selective positive allosteric modulator (PAM) PNU-120596, which were blocked by the α7-selective antagonist methyllycaconitine (MLA). In addition, a small proportion of the neurons express nAChRs with properties typical of heteromeric (non-α7 containing) nAChR subtypes. These cells therefore represent a great tool to advance our understanding of the properties of native human nAChRs, α7 in particular." @default.
• W2023852409 created "2016-06-24" @default.
• W2023852409 creator A5010098535 @default.
• W2023852409 creator A5015688257 @default.
• W2023852409 creator A5022754728 @default.
• W2023852409 creator A5043250344 @default.
• W2023852409 creator A5043911303 @default.
• W2023852409 creator A5053669541 @default.
• W2023852409 creator A5085986620 @default.
• W2023852409 date "2015-04-23" @default.
• W2023852409 modified "2023-09-26" @default.
• W2023852409 title "Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons" @default.
• W2023852409 cites W1513702727 @default.
• W2023852409 cites W1968461255 @default.
• W2023852409 cites W1971009901 @default.
• W2023852409 cites W1971784543 @default.
• W2023852409 cites W1999542553 @default.
• W2023852409 cites W2003298566 @default.
• W2023852409 cites W2003675844 @default.
• W2023852409 cites W2013032695 @default.
• W2023852409 cites W2020914828 @default.
• W2023852409 cites W2021710989 @default.
• W2023852409 cites W2023131483 @default.
• W2023852409 cites W2029954507 @default.
• W2023852409 cites W2033154101 @default.
• W2023852409 cites W2033877733 @default.
• W2023852409 cites W2039545195 @default.
• W2023852409 cites W2043908348 @default.
• W2023852409 cites W2050221047 @default.
• W2023852409 cites W2050406169 @default.
• W2023852409 cites W2060488758 @default.
• W2023852409 cites W2065561114 @default.
• W2023852409 cites W2072807117 @default.
• W2023852409 cites W2074617527 @default.
• W2023852409 cites W2079870118 @default.
• W2023852409 cites W2087786585 @default.
• W2023852409 cites W2092729144 @default.
• W2023852409 cites W2093484941 @default.
• W2023852409 cites W2111627512 @default.
• W2023852409 cites W2121262376 @default.
• W2023852409 cites W2124888321 @default.
• W2023852409 cites W2130407782 @default.
• W2023852409 cites W2133416984 @default.
• W2023852409 cites W2135507919 @default.
• W2023852409 cites W2138977668 @default.
• W2023852409 cites W2139173835 @default.
• W2023852409 cites W2140383855 @default.
• W2023852409 cites W2141458760 @default.
• W2023852409 cites W2144671685 @default.
• W2023852409 cites W2156076504 @default.
• W2023852409 cites W2157645703 @default.
• W2023852409 cites W2166904373 @default.
• W2023852409 cites W2301131921 @default.
• W2023852409 cites W4251365796 @default.
• W2023852409 doi "https://doi.org/10.1371/journal.pone.0125116" @default.
• W2023852409 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4408108" @default.
• W2023852409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25906356" @default.
• W2023852409 hasPublicationYear "2015" @default.
• W2023852409 type Work @default.
• W2023852409 sameAs 2023852409 @default.
• W2023852409 citedByCount "28" @default.
• W2023852409 countsByYear W20238524092015 @default.
• W2023852409 countsByYear W20238524092016 @default.
• W2023852409 countsByYear W20238524092017 @default.
• W2023852409 countsByYear W20238524092019 @default.
• W2023852409 countsByYear W20238524092020 @default.
• W2023852409 countsByYear W20238524092021 @default.
• W2023852409 countsByYear W20238524092022 @default.
• W2023852409 countsByYear W20238524092023 @default.
• W2023852409 crossrefType "journal-article" @default.
• W2023852409 hasAuthorship W2023852409A5010098535 @default.
• W2023852409 hasAuthorship W2023852409A5015688257 @default.
• W2023852409 hasAuthorship W2023852409A5022754728 @default.
• W2023852409 hasAuthorship W2023852409A5043250344 @default.
• W2023852409 hasAuthorship W2023852409A5043911303 @default.
• W2023852409 hasAuthorship W2023852409A5053669541 @default.
• W2023852409 hasAuthorship W2023852409A5085986620 @default.
• W2023852409 hasBestOaLocation W20238524091 @default.
• W2023852409 hasConcept C104317684 @default.
• W2023852409 hasConcept C107459253 @default.
• W2023852409 hasConcept C145103041 @default.
• W2023852409 hasConcept C147944092 @default.
• W2023852409 hasConcept C166342909 @default.
• W2023852409 hasConcept C169760540 @default.
• W2023852409 hasConcept C170493617 @default.
• W2023852409 hasConcept C185592680 @default.
• W2023852409 hasConcept C188987157 @default.
• W2023852409 hasConcept C2776038425 @default.
• W2023852409 hasConcept C2779570518 @default.
• W2023852409 hasConcept C2780374058 @default.
• W2023852409 hasConcept C50254741 @default.
• W2023852409 hasConcept C55493867 @default.
• W2023852409 hasConcept C61174792 @default.
• W2023852409 hasConcept C80161118 @default.
• W2023852409 hasConcept C82617044 @default.
• W2023852409 hasConcept C86803240 @default.
• W2023852409 hasConcept C95444343 @default.
• W2023852409 hasConceptScore W2023852409C104317684 @default.

• next