Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023852811> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2023852811 endingPage "1331" @default.
- W2023852811 startingPage "1328" @default.
- W2023852811 abstract "S-Adenosylmethionine is an essential ubiquitous metabolite central to many biochemical pathways, including transmethylation and polyamine biosynthesis. Reduced CSF S-adenosylmethionine levels in Alzheimer's disease have been reported; however, no information is available regarding the status of S-adenosylmethionine or S-adenosylmethionine-dependent methylation in the brain of patients with this disorder. S-Adenosylmethionine concentrations were measured in postmortem brain of 11 patients with Alzheimer's disease. We found decreased levels of S-adenosylmethionine (-67 to -85%) and its demethylated product S-adenosylhomocysteine (-56 to -79%) in all brain areas examined (cerebral cortical subdivisions, hippocampus, and putamen) as compared with matched controls (n = 14). S-Adenosylmethionine and S-adenosylhomocysteine levels were normal in occipital cortex of patients with idiopathic Parkinson's disease (n = 10), suggesting that the decreased S-adenosylmethionine levels in Alzheimer's disease are not simply a consequence of a chronic, neurodegenerative condition. Reduced S-adenosylmethionine levels could be due to excessive utilization in polyamine biosynthesis. The severe reduction in levels of this essential biochemical substrate would be expected to compromise seriously metabolism and brain function in patients with Alzheimer's disease and may provide the basis for the observations of improved cognition in some Alzheimer's patients following S-adenosylmethionine therapy." @default.
- W2023852811 created "2016-06-24" @default.
- W2023852811 creator A5000210550 @default.
- W2023852811 creator A5031376319 @default.
- W2023852811 creator A5086123605 @default.
- W2023852811 date "2002-11-23" @default.
- W2023852811 modified "2023-10-03" @default.
- W2023852811 title "Brain S-Adenosylmethionine Levels Are Severely Decreased in Alzheimer's Disease" @default.
- W2023852811 doi "https://doi.org/10.1046/j.1471-4159.1996.67031328.x" @default.
- W2023852811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8752143" @default.
- W2023852811 hasPublicationYear "2002" @default.
- W2023852811 type Work @default.
- W2023852811 sameAs 2023852811 @default.
- W2023852811 citedByCount "240" @default.
- W2023852811 countsByYear W20238528112012 @default.
- W2023852811 countsByYear W20238528112013 @default.
- W2023852811 countsByYear W20238528112014 @default.
- W2023852811 countsByYear W20238528112015 @default.
- W2023852811 countsByYear W20238528112016 @default.
- W2023852811 countsByYear W20238528112017 @default.
- W2023852811 countsByYear W20238528112018 @default.
- W2023852811 countsByYear W20238528112019 @default.
- W2023852811 countsByYear W20238528112020 @default.
- W2023852811 countsByYear W20238528112021 @default.
- W2023852811 countsByYear W20238528112022 @default.
- W2023852811 countsByYear W20238528112023 @default.
- W2023852811 crossrefType "journal-article" @default.
- W2023852811 hasAuthorship W2023852811A5000210550 @default.
- W2023852811 hasAuthorship W2023852811A5031376319 @default.
- W2023852811 hasAuthorship W2023852811A5086123605 @default.
- W2023852811 hasConcept C126322002 @default.
- W2023852811 hasConcept C134018914 @default.
- W2023852811 hasConcept C16568411 @default.
- W2023852811 hasConcept C169760540 @default.
- W2023852811 hasConcept C2779134260 @default.
- W2023852811 hasConcept C2779714222 @default.
- W2023852811 hasConcept C2780912031 @default.
- W2023852811 hasConcept C2781041448 @default.
- W2023852811 hasConcept C2781161787 @default.
- W2023852811 hasConcept C28774466 @default.
- W2023852811 hasConcept C39920043 @default.
- W2023852811 hasConcept C502032728 @default.
- W2023852811 hasConcept C515207424 @default.
- W2023852811 hasConcept C55493867 @default.
- W2023852811 hasConcept C71924100 @default.
- W2023852811 hasConcept C86803240 @default.
- W2023852811 hasConceptScore W2023852811C126322002 @default.
- W2023852811 hasConceptScore W2023852811C134018914 @default.
- W2023852811 hasConceptScore W2023852811C16568411 @default.
- W2023852811 hasConceptScore W2023852811C169760540 @default.
- W2023852811 hasConceptScore W2023852811C2779134260 @default.
- W2023852811 hasConceptScore W2023852811C2779714222 @default.
- W2023852811 hasConceptScore W2023852811C2780912031 @default.
- W2023852811 hasConceptScore W2023852811C2781041448 @default.
- W2023852811 hasConceptScore W2023852811C2781161787 @default.
- W2023852811 hasConceptScore W2023852811C28774466 @default.
- W2023852811 hasConceptScore W2023852811C39920043 @default.
- W2023852811 hasConceptScore W2023852811C502032728 @default.
- W2023852811 hasConceptScore W2023852811C515207424 @default.
- W2023852811 hasConceptScore W2023852811C55493867 @default.
- W2023852811 hasConceptScore W2023852811C71924100 @default.
- W2023852811 hasConceptScore W2023852811C86803240 @default.
- W2023852811 hasIssue "3" @default.
- W2023852811 hasLocation W20238528111 @default.
- W2023852811 hasLocation W20238528112 @default.
- W2023852811 hasOpenAccess W2023852811 @default.
- W2023852811 hasPrimaryLocation W20238528111 @default.
- W2023852811 hasRelatedWork W1972925419 @default.
- W2023852811 hasRelatedWork W1978555483 @default.
- W2023852811 hasRelatedWork W2000903685 @default.
- W2023852811 hasRelatedWork W2023852811 @default.
- W2023852811 hasRelatedWork W2036117787 @default.
- W2023852811 hasRelatedWork W2051488242 @default.
- W2023852811 hasRelatedWork W2051942816 @default.
- W2023852811 hasRelatedWork W2131377884 @default.
- W2023852811 hasRelatedWork W2375813713 @default.
- W2023852811 hasRelatedWork W2023428246 @default.
- W2023852811 hasVolume "67" @default.
- W2023852811 isParatext "false" @default.
- W2023852811 isRetracted "false" @default.
- W2023852811 magId "2023852811" @default.
- W2023852811 workType "article" @default.