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- W2023853831 abstract "The ability of glycated hemoglobin A1c (HbA1c) to predict diabetes is unknown, but could be evaluated by analyses on samples stored in biobanks. The stability of HbA1c in long-term stored samples is, however, unknown. Moreover, the effect of hemolysis on HbA1c in the general population is not assessed. To explore these questions HbA1c was determined in 3 groups (n = 717) of samples with storage times at −80°C differing between 10 years and 2 months. The results were compared with HbA1c analyzed in fresh blood samples (n = 174). The subjects were free from diabetes and aged 40 to 60 years. HbA1c was analyzed by cation exchange high-performance liquid chromatography (HPLC). The mean HbA1c results for the fresh and long-term stored samples were 4.25% ± 0.39 and 4.19% ± 0.43, respectively (P = not significant [NS]). The HbA1c levels in fresh and 2-month stored samples were essentially equal. There was no correlation between HbA1c in the fresh samples and the hemolysis parameters reticulocytes, haptoglobin, or bilirubin. HbA1c is apparently stable in samples long-term stored at −80°C and is not commonly affected by hemolysis in the general population. HbA1c analyzed on biobank samples could be used to assess the predictive value for future diabetes and relationship to other morbidity and mortality." @default.
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- W2023853831 date "2004-11-01" @default.
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- W2023853831 title "Hemoglobin A 1c can be analyzed in blood kept frozen at −80°C and is not commonly affected by hemolysis in the general population" @default.
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- W2023853831 doi "https://doi.org/10.1016/j.metabol.2004.04.015" @default.
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