Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023853890> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2023853890 endingPage "911" @default.
- W2023853890 startingPage "905" @default.
- W2023853890 abstract "The molecular nature of the defect in two mouse antigen processing-defective cell lines was examined. Both mutants were derived from the A20 (BALB/c, H2 d ) B cell line, and both were found to have defects in the H2-DMa gene. Mutant 3A5 exhibits severely reduced amounts of H2-DMa message, and no detectable DMα protein. cDNA sequence revealed a C → T transition at nucleotide 118, introducing a premature stop codon in exon 2 of the H2-DMa gene. In contrast, mutant 2A2 exhibits reduced but detectable levels of H2-DMa message and DMα protein only after treatment with IL-4, which induces the expression of both the H2-DMa and the H2-DMb genes in B cells. In this mutant the cDNA sequence revealed a missense mutation in exon 3 resulting in the conversion of a conserved proline residue in the Ig-like domain to serine. Stable transfection with full-length H2-DMa cDNA reconstitutes the antigen processing capacity of both mutants, as demonstrated by the ability to present native antigen to T cell clones, and by restored class II SDS stability." @default.
- W2023853890 created "2016-06-24" @default.
- W2023853890 creator A5060208706 @default.
- W2023853890 creator A5067500150 @default.
- W2023853890 creator A5082096834 @default.
- W2023853890 creator A5082781989 @default.
- W2023853890 date "1999-03-01" @default.
- W2023853890 modified "2023-10-16" @default.
- W2023853890 title "Class II antigen processing defects in twoH2 dmouse cell lines are caused by point mutations in theH2-DMagene" @default.
- W2023853890 cites W113162970 @default.
- W2023853890 cites W1482593395 @default.
- W2023853890 cites W1485559751 @default.
- W2023853890 cites W1557086683 @default.
- W2023853890 cites W1776397544 @default.
- W2023853890 cites W1928922925 @default.
- W2023853890 cites W1972970791 @default.
- W2023853890 cites W1976703529 @default.
- W2023853890 cites W1985132141 @default.
- W2023853890 cites W1993816545 @default.
- W2023853890 cites W1994915965 @default.
- W2023853890 cites W2001737867 @default.
- W2023853890 cites W2017936764 @default.
- W2023853890 cites W2018620812 @default.
- W2023853890 cites W2031124741 @default.
- W2023853890 cites W2034337614 @default.
- W2023853890 cites W2041524588 @default.
- W2023853890 cites W2068516158 @default.
- W2023853890 cites W2074222872 @default.
- W2023853890 cites W2083756044 @default.
- W2023853890 cites W2086210763 @default.
- W2023853890 cites W2087106927 @default.
- W2023853890 cites W2095352046 @default.
- W2023853890 cites W2096212030 @default.
- W2023853890 cites W2112260561 @default.
- W2023853890 cites W2121966286 @default.
- W2023853890 cites W4381156449 @default.
- W2023853890 doi "https://doi.org/10.1002/(sici)1521-4141(199903)29:03<905::aid-immu905>3.0.co;2-8" @default.
- W2023853890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10092094" @default.
- W2023853890 hasPublicationYear "1999" @default.
- W2023853890 type Work @default.
- W2023853890 sameAs 2023853890 @default.
- W2023853890 citedByCount "13" @default.
- W2023853890 countsByYear W20238538902012 @default.
- W2023853890 countsByYear W20238538902015 @default.
- W2023853890 countsByYear W20238538902017 @default.
- W2023853890 crossrefType "journal-article" @default.
- W2023853890 hasAuthorship W2023853890A5060208706 @default.
- W2023853890 hasAuthorship W2023853890A5067500150 @default.
- W2023853890 hasAuthorship W2023853890A5082096834 @default.
- W2023853890 hasAuthorship W2023853890A5082781989 @default.
- W2023853890 hasConcept C104317684 @default.
- W2023853890 hasConcept C143065580 @default.
- W2023853890 hasConcept C147483822 @default.
- W2023853890 hasConcept C153911025 @default.
- W2023853890 hasConcept C176944494 @default.
- W2023853890 hasConcept C187882448 @default.
- W2023853890 hasConcept C20580545 @default.
- W2023853890 hasConcept C36823959 @default.
- W2023853890 hasConcept C501734568 @default.
- W2023853890 hasConcept C54009773 @default.
- W2023853890 hasConcept C54355233 @default.
- W2023853890 hasConcept C75563809 @default.
- W2023853890 hasConcept C86803240 @default.
- W2023853890 hasConceptScore W2023853890C104317684 @default.
- W2023853890 hasConceptScore W2023853890C143065580 @default.
- W2023853890 hasConceptScore W2023853890C147483822 @default.
- W2023853890 hasConceptScore W2023853890C153911025 @default.
- W2023853890 hasConceptScore W2023853890C176944494 @default.
- W2023853890 hasConceptScore W2023853890C187882448 @default.
- W2023853890 hasConceptScore W2023853890C20580545 @default.
- W2023853890 hasConceptScore W2023853890C36823959 @default.
- W2023853890 hasConceptScore W2023853890C501734568 @default.
- W2023853890 hasConceptScore W2023853890C54009773 @default.
- W2023853890 hasConceptScore W2023853890C54355233 @default.
- W2023853890 hasConceptScore W2023853890C75563809 @default.
- W2023853890 hasConceptScore W2023853890C86803240 @default.
- W2023853890 hasIssue "3" @default.
- W2023853890 hasLocation W20238538901 @default.
- W2023853890 hasLocation W20238538902 @default.
- W2023853890 hasOpenAccess W2023853890 @default.
- W2023853890 hasPrimaryLocation W20238538901 @default.
- W2023853890 hasRelatedWork W2025348241 @default.
- W2023853890 hasRelatedWork W2086764801 @default.
- W2023853890 hasRelatedWork W2137098232 @default.
- W2023853890 hasRelatedWork W2352780564 @default.
- W2023853890 hasRelatedWork W2388007221 @default.
- W2023853890 hasRelatedWork W2997189992 @default.
- W2023853890 hasRelatedWork W3004443428 @default.
- W2023853890 hasRelatedWork W3153885336 @default.
- W2023853890 hasRelatedWork W4283010190 @default.
- W2023853890 hasRelatedWork W4361004911 @default.
- W2023853890 hasVolume "29" @default.
- W2023853890 isParatext "false" @default.
- W2023853890 isRetracted "false" @default.
- W2023853890 magId "2023853890" @default.
- W2023853890 workType "article" @default.