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- W2023857030 abstract "Objective : To investigate the efficacy of the cholesterol absorption inhibitor ezetimibe in patients with refractory familial hyperlipidaemia or intolerant to statin therapy.Methods : This prospective study assessed the safety and efficacy of ezetimibe in 200 patients with refractory familial hyperlipidaemias not achieving a low-density-lipoprotein (LDL) cholesterol < 3 mmol/L (116 mg/dL) including 22% intolerant to all statin therapy, many consuming sterol-containing products.Results : Ezetimibe monotherapy resulted in 7% and 11% reductions in LDL-cholesterol and apolipoprotein B respectively. Ezetimibe-statin combination therapy reduced LDL-cholesterol by an additional 11 ± 27% and apolipoprotein B by 11 (+79 to –18)%. There was a similar response between various sub-groups but a wide variation within groups with the greatest effect seen in patients under-responding to statins. The number of patients achieving the LDL‐C target of 3 mmol/L rose from 5.5% to 18%. Non-significant effects included a 5 (+78 to –470)% reduction in triglycerides, 8 ± 36% increment in HDL‐cholesterol, 21 (+35 to –82)% reduction in C-reactive protein and a 1 (+20 to –50)% increase in alanine transaminase. No effects were seen on creatinine, creatine kinase, or insulin resistance. Fourteen patients (7%) discontinued ezetimibe: seven due to gastrointestinal side-effects, one patient developed an ezetimibe-induced hypercholesterolaemia (× 1.5), one developed ezetimibe-induced hypertriglyceridaemia (× 7) and five discontinued for other reasons.Conclusion : Ezetimibe is a useful addition to statins in patients with familial hyperlipidaemias but shows a highly variable response profile." @default.
- W2023857030 created "2016-06-24" @default.
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- W2023857030 date "2005-02-22" @default.
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- W2023857030 title "Efficacy of ezetimibe in patients with statin-resistant and statin-intolerant familial hyperlipidaemias" @default.
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- W2023857030 doi "https://doi.org/10.1185/030079905x28872" @default.
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