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- W2023863267 abstract "Mutations in PARK8, encoding leucine-rich repeat kinase 2 (LRRK2), are a major cause of Parkinson's disease. We contrast data suggesting that changes in LRRK2 activity cause alterations in mitogen-activated protein kinase, translational control, tumor necrosis factor α/Fas ligand and Wnt signaling pathways with the cell biological functions of LRRK2 such as vesicle trafficking. Despite scarce in vivo data on cell signaling, involvement in diverse cell biological functions suggests a role for LRRK2 as an upstream regulator in events leading to neurodegeneration. To stimulate discussion and give direction for future research, we further suggest that despite the importance of the catalytic activity for cytotoxicity, the main cellular function of LRRK2 is linked to assembly of signaling complexes." @default.
- W2023863267 created "2016-06-24" @default.
- W2023863267 creator A5019147427 @default.
- W2023863267 creator A5021741148 @default.
- W2023863267 date "2011-05-01" @default.
- W2023863267 modified "2023-10-01" @default.
- W2023863267 title "LRRK2 signaling pathways: the key to unlocking neurodegeneration?" @default.
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- W2023863267 doi "https://doi.org/10.1016/j.tcb.2011.01.001" @default.
- W2023863267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21306901" @default.
- W2023863267 hasPublicationYear "2011" @default.
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