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- W2023863882 abstract "The values of C3 proactivator (C3PA) or properdin factor B, of early-acting complement components (C1q, C2, C4) and of C3 were measured in 35 voluntary blood donors and in 196 patients suffering from diseases known to involve the complement system, in order to evaluate the participation of the alternate pathway or properdin system in these patients. In systemic lupus erythematosus, in which values of the early-acting complement components were markedly decreased, there was a moderate decrease of C3PA. A recruitment effect by C3b (properdin factor A) may be the mechanism leading to this decrease of C3PA. By contrast, a selective activation of C3 by the alternate pathway may occur in hypocomplementemic membranoproliferative glomerulonephritis. Patients with this nephritis had low C3PA and low C3 values, while C3PA breakdown products were frequently detected in their plasma. In certain cases of chronic nephritis, hemolytic anemia and chronic carriers of Hepatitis B antigen, the complement profile suggests an activation of the complement system by the alternate pathway. Low values of C3PA were observed in severe liver cirrhosis, probably reflecting a hyposynthesis." @default.
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- W2023863882 date "1973-11-01" @default.
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- W2023863882 title "Quantitation of C3PA (properdin factor B) and other complement components in diseases associated with a low C3 level" @default.
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- W2023863882 doi "https://doi.org/10.1016/0090-1229(73)90032-9" @default.
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