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- W2023863994 abstract "Accumulating evidence reveals that aberrant expression of claudins manifests in various tumors; however, their biological functions are poorly understood. Here, we report on the elevated expression of claudin-1 in nasopharyngeal carcinoma (NPC) cell lines under serum deprivation or fluorouracil (5-FU) treatment. Interestingly, an increase in expression of claudin-1 considerably reduced apoptosis rather than enhancing cell proliferation. However, claudin-1 expression and activity were unaffected by external stimuli or Akt and NF-κB activation. Notably, predominant cytoplasmic and nuclear localization of claudin-1 in NPC cells reflected the aforementioned feature. On the other hand, loss of epithelial morphology and E-cadherin expression was associated with serum withdrawal in NPC cells. Interestingly, restoration of E-cadherin inhibited the protein elevation and antiapoptotic activity of claudin-1. In conclusion, our data demonstrate the regulation and novel biological function of claudin-1 and indicate the important role of claudin-1 in NPC tumorigenesis." @default.
- W2023863994 created "2016-06-24" @default.
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- W2023863994 date "2009-01-01" @default.
- W2023863994 modified "2023-09-30" @default.
- W2023863994 title "Upregulated claudin-1 expression confers resistance to cell death of nasopharyngeal carcinoma cells" @default.
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- W2023863994 doi "https://doi.org/10.1002/ijc.24857" @default.
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