Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023865095> ?p ?o ?g. }
- W2023865095 endingPage "199" @default.
- W2023865095 startingPage "181" @default.
- W2023865095 abstract "Excitatory amino acids may promote microtubular proteolysis observed in ischemic neuronal degeneration by calcium-mediated activation of calpain, a neutral protease. We tested this hypothesis in an animal model of focal cerebral ischemia without reperfusion. Spontaneously hypertensive rats were treated with 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo-(F)quinoxaline (NBQX), a competitive antagonist of the neuronal receptor for α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), or cis-4-[phosphono-methyl]-2-piperidine carboxylic acid (CGS 19755), a competitive antagonist of the N-methyl-d-aspartate (NMDA) receptor. After treatment, all animals were subjected to permanent occlusion of the middle cerebral artery for 6 or 24 h. Infarct volumes measured in animals pretreated with CGS 19755 after 24 h of ischemia were significantly smaller than those quantified in ischemic controls. Rats pretreated with NBQX showed partial amelioration of cytoskeletal injury with preserved immunolabeling of microtubule-associated protein 2 (MAP 2) at 6 and 24 h and reduced accumulation of calpain-cleaved spectrin byproducts only at 6 h. Prevention of cytoskeletal damage was more effective after pretreatment with CGS 19755, as shown by retention of MAP 2 immunolabeling and significant restriction of calpain activity at both 6 and 24 h. Preserved immunolabeling of tau protein was observed at 6 and 24 h only in animals pretreated with CGS 19755. Western analysis performed on ischemic cortex taken from controls or rats pretreated with either NBQX or CGS 19755 suggested that loss of tau protein immunoreactivity was caused by dephosphorylation, rather than proteolysis. These results demonstrate a crucial link between excitotoxic neurotransmission, microtubular proteolysis, and neuronal degeneration in focal cerebral ischemia." @default.
- W2023865095 created "2016-06-24" @default.
- W2023865095 creator A5003994463 @default.
- W2023865095 creator A5006769565 @default.
- W2023865095 creator A5039538989 @default.
- W2023865095 creator A5046533128 @default.
- W2023865095 creator A5063810993 @default.
- W2023865095 creator A5081479642 @default.
- W2023865095 creator A5085893830 @default.
- W2023865095 date "1998-11-01" @default.
- W2023865095 modified "2023-10-12" @default.
- W2023865095 title "Glutamate receptor antagonists inhibit calpain-mediated cytoskeletal proteolysis in focal cerebral ischemia" @default.
- W2023865095 cites W1509584111 @default.
- W2023865095 cites W1531327859 @default.
- W2023865095 cites W1569078050 @default.
- W2023865095 cites W1580653784 @default.
- W2023865095 cites W1626297236 @default.
- W2023865095 cites W1758246291 @default.
- W2023865095 cites W1820347542 @default.
- W2023865095 cites W1964915869 @default.
- W2023865095 cites W1967820002 @default.
- W2023865095 cites W1978015882 @default.
- W2023865095 cites W1979129896 @default.
- W2023865095 cites W1983548148 @default.
- W2023865095 cites W1987521464 @default.
- W2023865095 cites W1988086690 @default.
- W2023865095 cites W1990777624 @default.
- W2023865095 cites W1994030229 @default.
- W2023865095 cites W1995197669 @default.
- W2023865095 cites W2007562867 @default.
- W2023865095 cites W2008877912 @default.
- W2023865095 cites W2012316488 @default.
- W2023865095 cites W2013764865 @default.
- W2023865095 cites W2015308817 @default.
- W2023865095 cites W2016981332 @default.
- W2023865095 cites W2020622209 @default.
- W2023865095 cites W2021017365 @default.
- W2023865095 cites W2021860872 @default.
- W2023865095 cites W2023762813 @default.
- W2023865095 cites W2024868697 @default.
- W2023865095 cites W2026101249 @default.
- W2023865095 cites W2027093651 @default.
- W2023865095 cites W2029200092 @default.
- W2023865095 cites W2029394130 @default.
- W2023865095 cites W2035750459 @default.
- W2023865095 cites W2036755018 @default.
- W2023865095 cites W2036767869 @default.
- W2023865095 cites W2038910860 @default.
- W2023865095 cites W2040197139 @default.
- W2023865095 cites W2046452017 @default.
- W2023865095 cites W2048857548 @default.
- W2023865095 cites W2050098901 @default.
- W2023865095 cites W2050227915 @default.
- W2023865095 cites W2053354990 @default.
- W2023865095 cites W2053684219 @default.
- W2023865095 cites W2056734745 @default.
- W2023865095 cites W2059785302 @default.
- W2023865095 cites W2061984361 @default.
- W2023865095 cites W2068001868 @default.
- W2023865095 cites W2071961923 @default.
- W2023865095 cites W2073521129 @default.
- W2023865095 cites W2078382210 @default.
- W2023865095 cites W2080399942 @default.
- W2023865095 cites W2086015654 @default.
- W2023865095 cites W2086913809 @default.
- W2023865095 cites W2093947387 @default.
- W2023865095 cites W2095358033 @default.
- W2023865095 cites W2118432415 @default.
- W2023865095 cites W2125683177 @default.
- W2023865095 cites W2137726937 @default.
- W2023865095 cites W2143773297 @default.
- W2023865095 cites W2146638685 @default.
- W2023865095 cites W2158009878 @default.
- W2023865095 cites W2267906346 @default.
- W2023865095 cites W2341253028 @default.
- W2023865095 cites W4230147047 @default.
- W2023865095 cites W66689890 @default.
- W2023865095 doi "https://doi.org/10.1016/s0006-8993(98)00921-4" @default.
- W2023865095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9813316" @default.
- W2023865095 hasPublicationYear "1998" @default.
- W2023865095 type Work @default.
- W2023865095 sameAs 2023865095 @default.
- W2023865095 citedByCount "63" @default.
- W2023865095 countsByYear W20238650952013 @default.
- W2023865095 countsByYear W20238650952014 @default.
- W2023865095 countsByYear W20238650952015 @default.
- W2023865095 countsByYear W20238650952016 @default.
- W2023865095 countsByYear W20238650952018 @default.
- W2023865095 countsByYear W20238650952019 @default.
- W2023865095 crossrefType "journal-article" @default.
- W2023865095 hasAuthorship W2023865095A5003994463 @default.
- W2023865095 hasAuthorship W2023865095A5006769565 @default.
- W2023865095 hasAuthorship W2023865095A5039538989 @default.
- W2023865095 hasAuthorship W2023865095A5046533128 @default.
- W2023865095 hasAuthorship W2023865095A5063810993 @default.
- W2023865095 hasAuthorship W2023865095A5081479642 @default.
- W2023865095 hasAuthorship W2023865095A5085893830 @default.
- W2023865095 hasConcept C126322002 @default.