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- W2023867538 abstract "ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, was studied in the rat and cultured human fibroblasts. A marked increase in liver reductase was found in fed and fasted rats; there was no effect on cholesterol-7α-hydroxylase. ML-236B did not alter tissue sterol levels in fed or fasted rats. In fibroblasts from normal or familial hypercholesterolemic individuals, ML-236B caused a marked increase in reductase. In contrast, the incorporation [2-14C]-acetate into sterol was decreased while the incorporation into fatty acids was increased. Cycloheximide prevented the increase in fibroblast reductase." @default.
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- W2023867538 date "1978-05-01" @default.
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- W2023867538 title "Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B" @default.
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- W2023867538 doi "https://doi.org/10.1016/0006-291x(78)90602-2" @default.
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