FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023870033> ?p ?o ?g. }

• W2023870033 endingPage "1025" @default.
• W2023870033 startingPage "1012" @default.
• W2023870033 abstract "To evaluate the efficacy, tolerability, and safety of 3 different doses of divalproex sodium extended-release vs placebo in the prophylaxis of migraine headaches in adolescents.Divalproex sodium has been approved for migraine prophylaxis in adults, and previous uncontrolled data suggest divalproex sodium may be effective in preventing migraine in children and adolescents with acceptable tolerability.This was a 12-week, phase 3, randomized, placebo-controlled, double-blind, parallel-group, multicenter study in approximately 300 adolescents aged 12 to 17 years with migraine headaches. At the end of the baseline phase, subjects still meeting study criteria were randomized in a 1:1:1:1 ratio to receive divalproex sodium extended-release 250 mg, 500 mg, or 1000 mg once daily, or placebo. The primary efficacy variable was reduction from baseline in 4-week migraine headache rate for each active treatment group vs placebo. Standard safety assessments were conducted and testosterone and sex hormone-binding globulin levels were collected for postmenarchal females.There was no statistically significant treatment difference between any divalproex sodium extended-release dose group and placebo for the primary efficacy variable, reduction from baseline in 4-week migraine headache rate. There were no statistically significant differences in adverse events between any active treatment group and placebo. A notable dose-related decrease in platelets was observed, and individuals in all 4 treatment groups had increases in ammonia levels; treatment differences in other laboratory variables were generally small. Among postmenarchal female subjects who were not taking hormonal contraceptives or other steroids, there was no statistically significant change in testosterone levels, but a statistically significant dose-related increase in sex hormone-binding globulin was observed.In the current study, divalproex sodium extended-release did not differentiate from placebo in the prophylactic treatment of migraine headaches but was generally well-tolerated in adolescents aged 12 to 17 years." @default.
• W2023870033 created "2016-06-24" @default.
• W2023870033 creator A5006661051 @default.
• W2023870033 creator A5013822877 @default.
• W2023870033 creator A5034426466 @default.
• W2023870033 creator A5050931462 @default.
• W2023870033 creator A5067332869 @default.
• W2023870033 creator A5084396069 @default.
• W2023870033 creator A5087369453 @default.
• W2023870033 date "2008-07-01" @default.
• W2023870033 modified "2023-10-18" @default.
• W2023870033 title "Divalproex Extended-Release in Adolescent Migraine Prophylaxis: Results of a Randomized, Double-Blind, Placebo-Controlled Study" @default.
• W2023870033 cites W1727944881 @default.
• W2023870033 cites W1842552614 @default.
• W2023870033 cites W1963569078 @default.
• W2023870033 cites W1992369074 @default.
• W2023870033 cites W1996232705 @default.
• W2023870033 cites W1997130036 @default.
• W2023870033 cites W2005597677 @default.
• W2023870033 cites W2010777603 @default.
• W2023870033 cites W2010968829 @default.
• W2023870033 cites W2011887687 @default.
• W2023870033 cites W2021187061 @default.
• W2023870033 cites W2027432219 @default.
• W2023870033 cites W2046253759 @default.
• W2023870033 cites W2047455969 @default.
• W2023870033 cites W2052902333 @default.
• W2023870033 cites W2056798703 @default.
• W2023870033 cites W2066537633 @default.
• W2023870033 cites W2068520581 @default.
• W2023870033 cites W2069900520 @default.
• W2023870033 cites W2074860758 @default.
• W2023870033 cites W2075075391 @default.
• W2023870033 cites W2077714915 @default.
• W2023870033 cites W2082865944 @default.
• W2023870033 cites W2088520962 @default.
• W2023870033 cites W2095305121 @default.
• W2023870033 cites W2097701383 @default.
• W2023870033 cites W2103673483 @default.
• W2023870033 cites W2104817769 @default.
• W2023870033 cites W2127246721 @default.
• W2023870033 cites W2147394426 @default.
• W2023870033 cites W2149133494 @default.
• W2023870033 cites W2152007006 @default.
• W2023870033 cites W2158969140 @default.
• W2023870033 cites W2314331999 @default.
• W2023870033 doi "https://doi.org/10.1111/j.1526-4610.2008.01081.x" @default.
• W2023870033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18705027" @default.
• W2023870033 hasPublicationYear "2008" @default.
• W2023870033 type Work @default.
• W2023870033 sameAs 2023870033 @default.
• W2023870033 citedByCount "54" @default.
• W2023870033 countsByYear W20238700332012 @default.
• W2023870033 countsByYear W20238700332013 @default.
• W2023870033 countsByYear W20238700332014 @default.
• W2023870033 countsByYear W20238700332015 @default.
• W2023870033 countsByYear W20238700332016 @default.
• W2023870033 countsByYear W20238700332017 @default.
• W2023870033 countsByYear W20238700332018 @default.
• W2023870033 countsByYear W20238700332019 @default.
• W2023870033 countsByYear W20238700332020 @default.
• W2023870033 countsByYear W20238700332021 @default.
• W2023870033 countsByYear W20238700332022 @default.
• W2023870033 countsByYear W20238700332023 @default.
• W2023870033 crossrefType "journal-article" @default.
• W2023870033 hasAuthorship W2023870033A5006661051 @default.
• W2023870033 hasAuthorship W2023870033A5013822877 @default.
• W2023870033 hasAuthorship W2023870033A5034426466 @default.
• W2023870033 hasAuthorship W2023870033A5050931462 @default.
• W2023870033 hasAuthorship W2023870033A5067332869 @default.
• W2023870033 hasAuthorship W2023870033A5084396069 @default.
• W2023870033 hasAuthorship W2023870033A5087369453 @default.
• W2023870033 hasConcept C126322002 @default.
• W2023870033 hasConcept C141071460 @default.
• W2023870033 hasConcept C142724271 @default.
• W2023870033 hasConcept C168563851 @default.
• W2023870033 hasConcept C197934379 @default.
• W2023870033 hasConcept C204787440 @default.
• W2023870033 hasConcept C27081682 @default.
• W2023870033 hasConcept C2776174506 @default.
• W2023870033 hasConcept C2776809841 @default.
• W2023870033 hasConcept C2778375690 @default.
• W2023870033 hasConcept C2778541603 @default.
• W2023870033 hasConcept C2778541695 @default.
• W2023870033 hasConcept C2780966972 @default.
• W2023870033 hasConcept C2908949014 @default.
• W2023870033 hasConcept C42219234 @default.
• W2023870033 hasConcept C71924100 @default.
• W2023870033 hasConceptScore W2023870033C126322002 @default.
• W2023870033 hasConceptScore W2023870033C141071460 @default.
• W2023870033 hasConceptScore W2023870033C142724271 @default.
• W2023870033 hasConceptScore W2023870033C168563851 @default.
• W2023870033 hasConceptScore W2023870033C197934379 @default.
• W2023870033 hasConceptScore W2023870033C204787440 @default.
• W2023870033 hasConceptScore W2023870033C27081682 @default.
• W2023870033 hasConceptScore W2023870033C2776174506 @default.
• W2023870033 hasConceptScore W2023870033C2776809841 @default.
• W2023870033 hasConceptScore W2023870033C2778375690 @default.

• next