FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023871339> ?p ?o ?g. }

• W2023871339 endingPage "1615" @default.
• W2023871339 startingPage "1609" @default.
• W2023871339 abstract "1. The effect of the antidepressant drug, fluoxetine on neuronal delayed rectifier (KV) potassium (K) currents was investigated using perforated-patch whole-cell electrophysiological recording methods. 2. Fluoxetine was an effective inhibitor of KV currents in cerebellar granule neurons (CGNs) and also inhibited recombinant KV1.1 channels expressed in Chinese hamster ovary (CHO) cells. 3. Fluoxetine had an IC50 of 11 microM in CGNs but was slightly less potent on KV1.1 channels (IC50=55 microM). Interestingly, fluoxetine was a much more potent inhibitor of KV1.1 expressed in mammalian cells than has been found previously for the same homomeric channel expressed in Xenopus oocytes. 4. At concentrations that produced around 50% block, the shape of the KV currents in the presence of fluoxetine was simply scaled down when compared to control currents. 5. The effect of fluoxetine on KV currents in CGNs was neither voltage-dependent nor dependent on the channels being in their open state. Both of these observations suggest that fluoxetine does not act as a simple open channel blocking agent. 6. It is concluded that block of KV currents in mammalian neurons can occur at therapeutic levels of fluoxetine. This could lead to an increase in neuronal excitability and this effect may contribute to the therapeutic antidepressant action of fluoxetine." @default.
• W2023871339 created "2016-06-24" @default.
• W2023871339 creator A5014692107 @default.
• W2023871339 creator A5031256447 @default.
• W2023871339 creator A5054144477 @default.
• W2023871339 date "1999-12-01" @default.
• W2023871339 modified "2023-09-26" @default.
• W2023871339 title "Inhibition of neuronal K_V potassium currents by the antidepressant drug, fluoxetine" @default.
• W2023871339 cites W1900387932 @default.
• W2023871339 cites W1976750269 @default.
• W2023871339 cites W1979006676 @default.
• W2023871339 cites W1982473946 @default.
• W2023871339 cites W1982728552 @default.
• W2023871339 cites W1995115128 @default.
• W2023871339 cites W1999788892 @default.
• W2023871339 cites W2006957979 @default.
• W2023871339 cites W2009482685 @default.
• W2023871339 cites W2012001732 @default.
• W2023871339 cites W2017394635 @default.
• W2023871339 cites W2017903457 @default.
• W2023871339 cites W2026409252 @default.
• W2023871339 cites W2028484749 @default.
• W2023871339 cites W2029302344 @default.
• W2023871339 cites W2031314404 @default.
• W2023871339 cites W2033931931 @default.
• W2023871339 cites W2047905951 @default.
• W2023871339 cites W2048268501 @default.
• W2023871339 cites W2057657052 @default.
• W2023871339 cites W2062963816 @default.
• W2023871339 cites W2067091061 @default.
• W2023871339 cites W2071546813 @default.
• W2023871339 cites W2080378360 @default.
• W2023871339 cites W2081931314 @default.
• W2023871339 cites W2128687833 @default.
• W2023871339 cites W2338518233 @default.
• W2023871339 cites W2465651915 @default.
• W2023871339 cites W4243201595 @default.
• W2023871339 cites W4247804440 @default.
• W2023871339 doi "https://doi.org/10.1038/sj.bjp.0702955" @default.
• W2023871339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1571791" @default.
• W2023871339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10602343" @default.
• W2023871339 hasPublicationYear "1999" @default.
• W2023871339 type Work @default.
• W2023871339 sameAs 2023871339 @default.
• W2023871339 citedByCount "53" @default.
• W2023871339 countsByYear W20238713392012 @default.
• W2023871339 countsByYear W20238713392013 @default.
• W2023871339 countsByYear W20238713392014 @default.
• W2023871339 countsByYear W20238713392015 @default.
• W2023871339 countsByYear W20238713392016 @default.
• W2023871339 countsByYear W20238713392017 @default.
• W2023871339 countsByYear W20238713392018 @default.
• W2023871339 countsByYear W20238713392023 @default.
• W2023871339 crossrefType "journal-article" @default.
• W2023871339 hasAuthorship W2023871339A5014692107 @default.
• W2023871339 hasAuthorship W2023871339A5031256447 @default.
• W2023871339 hasAuthorship W2023871339A5054144477 @default.
• W2023871339 hasBestOaLocation W20238713391 @default.
• W2023871339 hasConcept C104317684 @default.
• W2023871339 hasConcept C12554922 @default.
• W2023871339 hasConcept C147944092 @default.
• W2023871339 hasConcept C169760540 @default.
• W2023871339 hasConcept C170493617 @default.
• W2023871339 hasConcept C17077164 @default.
• W2023871339 hasConcept C175656101 @default.
• W2023871339 hasConcept C185263204 @default.
• W2023871339 hasConcept C185592680 @default.
• W2023871339 hasConcept C2775864247 @default.
• W2023871339 hasConcept C2776134451 @default.
• W2023871339 hasConcept C2778457506 @default.
• W2023871339 hasConcept C2779177272 @default.
• W2023871339 hasConcept C2779535977 @default.
• W2023871339 hasConcept C2781161787 @default.
• W2023871339 hasConcept C55493867 @default.
• W2023871339 hasConcept C83743174 @default.
• W2023871339 hasConcept C86803240 @default.
• W2023871339 hasConcept C98274493 @default.
• W2023871339 hasConceptScore W2023871339C104317684 @default.
• W2023871339 hasConceptScore W2023871339C12554922 @default.
• W2023871339 hasConceptScore W2023871339C147944092 @default.
• W2023871339 hasConceptScore W2023871339C169760540 @default.
• W2023871339 hasConceptScore W2023871339C170493617 @default.
• W2023871339 hasConceptScore W2023871339C17077164 @default.
• W2023871339 hasConceptScore W2023871339C175656101 @default.
• W2023871339 hasConceptScore W2023871339C185263204 @default.
• W2023871339 hasConceptScore W2023871339C185592680 @default.
• W2023871339 hasConceptScore W2023871339C2775864247 @default.
• W2023871339 hasConceptScore W2023871339C2776134451 @default.
• W2023871339 hasConceptScore W2023871339C2778457506 @default.
• W2023871339 hasConceptScore W2023871339C2779177272 @default.
• W2023871339 hasConceptScore W2023871339C2779535977 @default.
• W2023871339 hasConceptScore W2023871339C2781161787 @default.
• W2023871339 hasConceptScore W2023871339C55493867 @default.
• W2023871339 hasConceptScore W2023871339C83743174 @default.
• W2023871339 hasConceptScore W2023871339C86803240 @default.
• W2023871339 hasConceptScore W2023871339C98274493 @default.
• W2023871339 hasIssue "7" @default.
• W2023871339 hasLocation W20238713391 @default.

• next