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• W2023871512 abstract "Kainic acid-induced seizures in rats represent an established animal model for human temporal lobe epilepsy. The neuropathological sequelae include acute status epilepticus followed by neurodegeneration in the CA1 and CA3 sector of the Ammon's horn and of interneurons in the hilus of the dentate gyrus. After about three weeks spontaneous recurrent seizures become manifest. We investigated changes in messenger RNA expression of 13 GABAA receptor subunits in the hippocampus of rats in the initial phase (6 h, 12 h and 24 h) after acute kainic acid-induced status epilepticus and seizure-related neuronal cell damage during and after acquisition of spontaneous recurrent seizures (seven and 30 days after kainic acid injection). In the granule cell layer, initial (after 6 to 12 h) decreases in (α2, α3, α5, β1, β3, γ2 and δ messenger RNAs (by about 25 to 50%) were accompanied by increases (by about 50%) in α1, α4, and β2 messages. At later intervals (after seven to 30 days), expression of α2, α4, β3 and γ2 messenger RNAs recovered to control values, with α5 and δ messenger RNA still being reduced (by 15 and 40% below control levels, respectively). Concentrations of the transcripts encoding for α1, α3, β1, β2, became markedly enhanced (between 20 and 50% of controls). Within the pyramidal cell layers CA1 and CA3, decreases in α2, α4, α5, β1–3 and γ2 messenger RNAs were detected after seven to 30 days, reflecting pronounced neurodegeneration in these areas. The α1 transcript was decreased in CA3 after 24 h and increased to control levels indicating compensatory up-regulation of this message after seven days. Messenger RNAs encoding for α3-, γ1-, and γ3-subunits were detected at rather low levels, α6 was not present in the hippocampus. Our data suggest a fast but transient change in the expression of messenger RNAs encoding for different subunits of the GABAA receptor in the granule cell layer of the dentate gyrus. This is followed by a lasting augmentation of messenger RNAs encoding different GABAA receptor subunits in the same cell layer indicating long-lasting GABAergic inhibition. Changes within the pyramidal cell layer are mostly determined by concomitant neurodegenerative processes." @default.
• W2023871512 created "2016-06-24" @default.
• W2023871512 creator A5011710896 @default.
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• W2023871512 date "1997-08-01" @default.
• W2023871512 modified "2023-10-18" @default.
• W2023871512 title "GABAA receptor subunits in the rat hippocampus III: altered messenger RNA expression in kainic acid-induced epilepsy" @default.
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• W2023871512 doi "https://doi.org/10.1016/s0306-4522(97)00144-9" @default.
• W2023871512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9284057" @default.
• W2023871512 hasPublicationYear "1997" @default.
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