Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023871567> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2023871567 endingPage "41" @default.
- W2023871567 startingPage "37" @default.
- W2023871567 abstract "BACKGROUND Single dose diethylcarbamazine (DEC) as used in control programmes is effectively microfilaricidal for periods of up to a year or more but has incomplete ability to kill Wuchereria bancrofti adult parasites. These regimens can be effective in breaking transmission by suppression of circulating microfilariae available to mosquito vectors. Whether prolonged or aggressive therapy with DEC has a significant effect on adult worms, which may live up to 12 years or more, and is important in the context of the treatment of individual patients, is still incompletely understood. METHODS In order to investigate the adulticidal effect of aggressive therapy, DEC was given at 6 mg/kg/day for 12‐day courses at 0, 6, 12, and 18 months and Og4C3 antigenaemia followed over two years in 38 CAg + Brazilians in a W. bancrofti endemic area. RESULTS At two year follow‐up, the median level of antigenaemia was 21% of the pre‐treatment value. 92% of individuals had antigen levels < 50% of pretreatment values, but only 26% had completely cleared antigenaemia. The clearance rate at 24 months was only 12% (3/26) in the asymptomatic CAg + patients but 58% (7/12) in those with clinical manifestations of filariasis. The latter individuals cleared significantly more antigen (median of 0% pretreatment antigenaemia vs. 26%; P =0.02) than asymptomatic but infected individuals. CONCLUSION Aggressive repeated therapy with DEC alone is ineffective in consistently eradicating adult W. bancrofti , especially in infected but asymptomatic individuals. Prolonged courses of combination therapy with other antifilarial drugs should be investigated for treatment of individual patients with the means to pursue aggressive personal medical care." @default.
- W2023871567 created "2016-06-24" @default.
- W2023871567 creator A5007579126 @default.
- W2023871567 creator A5011148065 @default.
- W2023871567 creator A5042954102 @default.
- W2023871567 creator A5064632372 @default.
- W2023871567 creator A5069048753 @default.
- W2023871567 creator A5079103060 @default.
- W2023871567 date "2001-01-01" @default.
- W2023871567 modified "2023-10-15" @default.
- W2023871567 title "Effect of aggressive prolonged diethylcarbamazine therapy on circulating antigen levels in bancroftian filariasis" @default.
- W2023871567 cites W1986081900 @default.
- W2023871567 cites W1990721074 @default.
- W2023871567 cites W1991279333 @default.
- W2023871567 cites W2011785610 @default.
- W2023871567 cites W2017989202 @default.
- W2023871567 cites W2106774610 @default.
- W2023871567 cites W2116133893 @default.
- W2023871567 cites W2125206959 @default.
- W2023871567 cites W2302105412 @default.
- W2023871567 cites W2463369934 @default.
- W2023871567 doi "https://doi.org/10.1046/j.1365-3156.2001.00666.x" @default.
- W2023871567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11251894" @default.
- W2023871567 hasPublicationYear "2001" @default.
- W2023871567 type Work @default.
- W2023871567 sameAs 2023871567 @default.
- W2023871567 citedByCount "30" @default.
- W2023871567 countsByYear W20238715672012 @default.
- W2023871567 countsByYear W20238715672013 @default.
- W2023871567 countsByYear W20238715672014 @default.
- W2023871567 countsByYear W20238715672015 @default.
- W2023871567 countsByYear W20238715672017 @default.
- W2023871567 countsByYear W20238715672018 @default.
- W2023871567 countsByYear W20238715672019 @default.
- W2023871567 crossrefType "journal-article" @default.
- W2023871567 hasAuthorship W2023871567A5007579126 @default.
- W2023871567 hasAuthorship W2023871567A5011148065 @default.
- W2023871567 hasAuthorship W2023871567A5042954102 @default.
- W2023871567 hasAuthorship W2023871567A5064632372 @default.
- W2023871567 hasAuthorship W2023871567A5069048753 @default.
- W2023871567 hasAuthorship W2023871567A5079103060 @default.
- W2023871567 hasBestOaLocation W20238715671 @default.
- W2023871567 hasConcept C126322002 @default.
- W2023871567 hasConcept C126894567 @default.
- W2023871567 hasConcept C138944611 @default.
- W2023871567 hasConcept C151730666 @default.
- W2023871567 hasConcept C165901193 @default.
- W2023871567 hasConcept C203014093 @default.
- W2023871567 hasConcept C2776908094 @default.
- W2023871567 hasConcept C2777411658 @default.
- W2023871567 hasConcept C2777629521 @default.
- W2023871567 hasConcept C2777910003 @default.
- W2023871567 hasConcept C2778672586 @default.
- W2023871567 hasConcept C2779343474 @default.
- W2023871567 hasConcept C2779726973 @default.
- W2023871567 hasConcept C42407357 @default.
- W2023871567 hasConcept C42972112 @default.
- W2023871567 hasConcept C71924100 @default.
- W2023871567 hasConcept C86803240 @default.
- W2023871567 hasConcept C90924648 @default.
- W2023871567 hasConceptScore W2023871567C126322002 @default.
- W2023871567 hasConceptScore W2023871567C126894567 @default.
- W2023871567 hasConceptScore W2023871567C138944611 @default.
- W2023871567 hasConceptScore W2023871567C151730666 @default.
- W2023871567 hasConceptScore W2023871567C165901193 @default.
- W2023871567 hasConceptScore W2023871567C203014093 @default.
- W2023871567 hasConceptScore W2023871567C2776908094 @default.
- W2023871567 hasConceptScore W2023871567C2777411658 @default.
- W2023871567 hasConceptScore W2023871567C2777629521 @default.
- W2023871567 hasConceptScore W2023871567C2777910003 @default.
- W2023871567 hasConceptScore W2023871567C2778672586 @default.
- W2023871567 hasConceptScore W2023871567C2779343474 @default.
- W2023871567 hasConceptScore W2023871567C2779726973 @default.
- W2023871567 hasConceptScore W2023871567C42407357 @default.
- W2023871567 hasConceptScore W2023871567C42972112 @default.
- W2023871567 hasConceptScore W2023871567C71924100 @default.
- W2023871567 hasConceptScore W2023871567C86803240 @default.
- W2023871567 hasConceptScore W2023871567C90924648 @default.
- W2023871567 hasIssue "1" @default.
- W2023871567 hasLocation W20238715671 @default.
- W2023871567 hasLocation W20238715672 @default.
- W2023871567 hasOpenAccess W2023871567 @default.
- W2023871567 hasPrimaryLocation W20238715671 @default.
- W2023871567 hasRelatedWork W1542219589 @default.
- W2023871567 hasRelatedWork W2049741828 @default.
- W2023871567 hasRelatedWork W2063971170 @default.
- W2023871567 hasRelatedWork W2078475883 @default.
- W2023871567 hasRelatedWork W2138057493 @default.
- W2023871567 hasRelatedWork W2271404707 @default.
- W2023871567 hasRelatedWork W2402272412 @default.
- W2023871567 hasRelatedWork W2413665020 @default.
- W2023871567 hasRelatedWork W2587906453 @default.
- W2023871567 hasRelatedWork W295255601 @default.
- W2023871567 hasVolume "6" @default.
- W2023871567 isParatext "false" @default.
- W2023871567 isRetracted "false" @default.
- W2023871567 magId "2023871567" @default.
- W2023871567 workType "article" @default.