Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023873386> ?p ?o ?g. }
- W2023873386 endingPage "380" @default.
- W2023873386 startingPage "368" @default.
- W2023873386 abstract "In this study, the time course of schisandrin B- (Sch B-) induced changes in hepatic mitochondrial glutathione antioxidant status (mtGAS) and heat shock protein (HSP) 25/70 induction was examined to study their differential roles in the hepatoprotection afforded by Sch B pretreatment against carbon tetrachloride (CCl(4)) toxicity in mice. Dimethyl diphenyl bicarboxylate (DDB), a nonhepatoprotective analog of Sch B, was also included for comparison. The results indicate that Sch B treatment (2 mmol/kg) produced maximum enhancement in hepatic mtGAS and increases in both hepatic HSP 25 and HSP 70 levels at 24 h after dosing. While the extent of hepatoprotection afforded by Sch B pretreatment against CCl(4) was found to correlate inversely with the elapsed time postdosing, the protective effect was associated with the ability to sustain mtGAS and/or HSP 70 levels in a CCl(4)-intoxicated condition. On the other hand, DDB (2 mmol/kg) treatment, which did not sustain mtGAS and HSP 70 level, could not protect against CCl(4) toxicity. Abolition of the Sch B-mediated enhancement of mtGAS by buthionine sulfoximine/phorone did not completely abrogate the hepatoprotective action of Sch B. The results indicate that Sch B pretreatment independently enhances mtGAS and induces HSP 25/70 production, particularly under conditions of oxidative stress, thereby protecting against CCl(4) hepatotoxicity." @default.
- W2023873386 created "2016-06-24" @default.
- W2023873386 creator A5007868512 @default.
- W2023873386 creator A5010432720 @default.
- W2023873386 creator A5030267865 @default.
- W2023873386 creator A5034434552 @default.
- W2023873386 creator A5076817189 @default.
- W2023873386 date "2003-08-01" @default.
- W2023873386 modified "2023-10-16" @default.
- W2023873386 title "Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins" @default.
- W2023873386 cites W113297332 @default.
- W2023873386 cites W1504187225 @default.
- W2023873386 cites W1526199338 @default.
- W2023873386 cites W1554862107 @default.
- W2023873386 cites W1559822664 @default.
- W2023873386 cites W1564588771 @default.
- W2023873386 cites W1683598352 @default.
- W2023873386 cites W1769448430 @default.
- W2023873386 cites W1875662288 @default.
- W2023873386 cites W1964179041 @default.
- W2023873386 cites W1964439911 @default.
- W2023873386 cites W1966041826 @default.
- W2023873386 cites W1977388184 @default.
- W2023873386 cites W2004125695 @default.
- W2023873386 cites W2005383788 @default.
- W2023873386 cites W2010225757 @default.
- W2023873386 cites W2012185275 @default.
- W2023873386 cites W2019079217 @default.
- W2023873386 cites W2040904544 @default.
- W2023873386 cites W2043121948 @default.
- W2023873386 cites W2043459592 @default.
- W2023873386 cites W2043817490 @default.
- W2023873386 cites W2046639009 @default.
- W2023873386 cites W2056617776 @default.
- W2023873386 cites W2058337632 @default.
- W2023873386 cites W2059201682 @default.
- W2023873386 cites W2059481807 @default.
- W2023873386 cites W2063252913 @default.
- W2023873386 cites W2070856983 @default.
- W2023873386 cites W2082483596 @default.
- W2023873386 cites W2083239315 @default.
- W2023873386 cites W2094600566 @default.
- W2023873386 cites W2138024770 @default.
- W2023873386 cites W2174879024 @default.
- W2023873386 cites W304632472 @default.
- W2023873386 cites W4245957869 @default.
- W2023873386 doi "https://doi.org/10.1016/s0891-5849(03)00274-0" @default.
- W2023873386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12899939" @default.
- W2023873386 hasPublicationYear "2003" @default.
- W2023873386 type Work @default.
- W2023873386 sameAs 2023873386 @default.
- W2023873386 citedByCount "70" @default.
- W2023873386 countsByYear W20238733862012 @default.
- W2023873386 countsByYear W20238733862013 @default.
- W2023873386 countsByYear W20238733862014 @default.
- W2023873386 countsByYear W20238733862015 @default.
- W2023873386 countsByYear W20238733862016 @default.
- W2023873386 countsByYear W20238733862017 @default.
- W2023873386 countsByYear W20238733862018 @default.
- W2023873386 countsByYear W20238733862019 @default.
- W2023873386 countsByYear W20238733862020 @default.
- W2023873386 countsByYear W20238733862021 @default.
- W2023873386 countsByYear W20238733862022 @default.
- W2023873386 crossrefType "journal-article" @default.
- W2023873386 hasAuthorship W2023873386A5007868512 @default.
- W2023873386 hasAuthorship W2023873386A5010432720 @default.
- W2023873386 hasAuthorship W2023873386A5030267865 @default.
- W2023873386 hasAuthorship W2023873386A5034434552 @default.
- W2023873386 hasAuthorship W2023873386A5076817189 @default.
- W2023873386 hasConcept C104317684 @default.
- W2023873386 hasConcept C178790620 @default.
- W2023873386 hasConcept C181199279 @default.
- W2023873386 hasConcept C185592680 @default.
- W2023873386 hasConcept C205260736 @default.
- W2023873386 hasConcept C2776151105 @default.
- W2023873386 hasConcept C2776514860 @default.
- W2023873386 hasConcept C2777359374 @default.
- W2023873386 hasConcept C2777476445 @default.
- W2023873386 hasConcept C2778004101 @default.
- W2023873386 hasConcept C29730261 @default.
- W2023873386 hasConcept C538909803 @default.
- W2023873386 hasConcept C55493867 @default.
- W2023873386 hasConcept C68991219 @default.
- W2023873386 hasConcept C86803240 @default.
- W2023873386 hasConcept C98274493 @default.
- W2023873386 hasConceptScore W2023873386C104317684 @default.
- W2023873386 hasConceptScore W2023873386C178790620 @default.
- W2023873386 hasConceptScore W2023873386C181199279 @default.
- W2023873386 hasConceptScore W2023873386C185592680 @default.
- W2023873386 hasConceptScore W2023873386C205260736 @default.
- W2023873386 hasConceptScore W2023873386C2776151105 @default.
- W2023873386 hasConceptScore W2023873386C2776514860 @default.
- W2023873386 hasConceptScore W2023873386C2777359374 @default.
- W2023873386 hasConceptScore W2023873386C2777476445 @default.
- W2023873386 hasConceptScore W2023873386C2778004101 @default.
- W2023873386 hasConceptScore W2023873386C29730261 @default.
- W2023873386 hasConceptScore W2023873386C538909803 @default.
- W2023873386 hasConceptScore W2023873386C55493867 @default.