FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023874086> ?p ?o ?g. }

• W2023874086 endingPage "174" @default.
• W2023874086 startingPage "166" @default.
• W2023874086 abstract "The objectives of this work were to evaluate the direct effects of diallysulfide (DAS) and diallyldisulfide (DADS), two major organosulfur compounds of garlic oil, on mitochondrial function and integrity, by using isolated mouse liver mitochondria in a cell-free system. DADS produced concentration-dependent mitochondrial swelling over the range 125–1000 μM, while DAS was ineffective. Swelling experiments performed with de-energized or energized mitochondria showed similar maximal swelling amplitudes. Cyclosporin A (1 μM), or ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid (EGTA, 1 mM) were ineffective in inhibiting DADS-induced mitochondrial swelling. DADS produced a minor (12%) decrease in mitochondrial membrane protein thiols, but did not induce clustering of mitochondrial membrane proteins. Incubation of mitochondria with DADS (but not DAS) produced an increase in the oxidation rate of 2′,7′ dichlorofluorescein diacetate (DCFH-DA), together with depletion of reduced glutathione (GSH) and increased lipid peroxidation. DADS (but not DAS) produced a concentration-dependent dissipation of the mitochondrial membrane potential, but did not induce cytochrome c release. DADS-dependent effects, including mitochondrial swelling, DCFH-DA oxidation, lipid peroxidation and loss of mitochondrial membrane potential, were inhibited by antioxidants and iron chelators. These results suggest that DADS causes direct impairment of mitochondrial function as the result of oxidation of the membrane lipid phase initiated by the GSH- and iron-dependent generation of oxidants." @default.
• W2023874086 created "2016-06-24" @default.
• W2023874086 creator A5029475245 @default.
• W2023874086 creator A5048469332 @default.
• W2023874086 creator A5052684659 @default.
• W2023874086 creator A5055041747 @default.
• W2023874086 creator A5074759544 @default.
• W2023874086 creator A5085555721 @default.
• W2023874086 date "2012-10-01" @default.
• W2023874086 modified "2023-09-26" @default.
• W2023874086 title "Effect of garlic-derived organosulfur compounds on mitochondrial function and integrity in isolated mouse liver mitochondria" @default.
• W2023874086 cites W1487157100 @default.
• W2023874086 cites W1490042920 @default.
• W2023874086 cites W1492823505 @default.
• W2023874086 cites W1964483580 @default.
• W2023874086 cites W1968517023 @default.
• W2023874086 cites W1972100019 @default.
• W2023874086 cites W1972708600 @default.
• W2023874086 cites W1972733192 @default.
• W2023874086 cites W1975650473 @default.
• W2023874086 cites W1979731389 @default.
• W2023874086 cites W1980357776 @default.
• W2023874086 cites W1985731963 @default.
• W2023874086 cites W1989351238 @default.
• W2023874086 cites W1989385622 @default.
• W2023874086 cites W1990472260 @default.
• W2023874086 cites W1997171049 @default.
• W2023874086 cites W1997684038 @default.
• W2023874086 cites W2002948867 @default.
• W2023874086 cites W2005571058 @default.
• W2023874086 cites W2006965710 @default.
• W2023874086 cites W2011659617 @default.
• W2023874086 cites W2014131894 @default.
• W2023874086 cites W2019403369 @default.
• W2023874086 cites W2025454755 @default.
• W2023874086 cites W2029185973 @default.
• W2023874086 cites W2034676721 @default.
• W2023874086 cites W2034711771 @default.
• W2023874086 cites W2036127346 @default.
• W2023874086 cites W2050583436 @default.
• W2023874086 cites W2051735533 @default.
• W2023874086 cites W2056563430 @default.
• W2023874086 cites W2060013956 @default.
• W2023874086 cites W2061131069 @default.
• W2023874086 cites W2062253540 @default.
• W2023874086 cites W2065786940 @default.
• W2023874086 cites W2070764343 @default.
• W2023874086 cites W2074423796 @default.
• W2023874086 cites W2083799357 @default.
• W2023874086 cites W2086318604 @default.
• W2023874086 cites W2094120111 @default.
• W2023874086 cites W2094169324 @default.
• W2023874086 cites W2094450904 @default.
• W2023874086 cites W2095423685 @default.
• W2023874086 cites W2108227374 @default.
• W2023874086 cites W2120701804 @default.
• W2023874086 cites W2134388096 @default.
• W2023874086 cites W2136309049 @default.
• W2023874086 cites W2141265286 @default.
• W2023874086 cites W2143038744 @default.
• W2023874086 cites W2144277227 @default.
• W2023874086 cites W2169153978 @default.
• W2023874086 cites W2199486122 @default.
• W2023874086 cites W2398664613 @default.
• W2023874086 doi "https://doi.org/10.1016/j.toxlet.2012.08.017" @default.
• W2023874086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3535879" @default.
• W2023874086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22960305" @default.
• W2023874086 hasPublicationYear "2012" @default.
• W2023874086 type Work @default.
• W2023874086 sameAs 2023874086 @default.
• W2023874086 citedByCount "59" @default.
• W2023874086 countsByYear W20238740862013 @default.
• W2023874086 countsByYear W20238740862014 @default.
• W2023874086 countsByYear W20238740862016 @default.
• W2023874086 countsByYear W20238740862017 @default.
• W2023874086 countsByYear W20238740862018 @default.
• W2023874086 countsByYear W20238740862019 @default.
• W2023874086 countsByYear W20238740862020 @default.
• W2023874086 countsByYear W20238740862021 @default.
• W2023874086 countsByYear W20238740862022 @default.
• W2023874086 countsByYear W20238740862023 @default.
• W2023874086 crossrefType "journal-article" @default.
• W2023874086 hasAuthorship W2023874086A5029475245 @default.
• W2023874086 hasAuthorship W2023874086A5048469332 @default.
• W2023874086 hasAuthorship W2023874086A5052684659 @default.
• W2023874086 hasAuthorship W2023874086A5055041747 @default.
• W2023874086 hasAuthorship W2023874086A5074759544 @default.
• W2023874086 hasAuthorship W2023874086A5085555721 @default.
• W2023874086 hasBestOaLocation W20238740862 @default.
• W2023874086 hasConcept C12554922 @default.
• W2023874086 hasConcept C181199279 @default.
• W2023874086 hasConcept C185592680 @default.
• W2023874086 hasConcept C2776151105 @default.
• W2023874086 hasConcept C2780829032 @default.
• W2023874086 hasConcept C28859421 @default.
• W2023874086 hasConcept C48349386 @default.
• W2023874086 hasConcept C538909803 @default.
• W2023874086 hasConcept C55493867 @default.

• next