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- W2023876067 abstract "Recently, it has been reported that aristolochic acid inhibits phospholipase A2 (PLA2in vitro and also decrease either oedema induced by snake venom and human synovial fluid PLA2. The aim of this research was to study the antiiflammatory activity of aristolochic acid and to investigate the effect of the alkaloid on the enzymes involved in the release of eicosanoids. Our results demonstrate that aristolochic acid is able to inhibit inflammation induced by immunological, immune complexes, and nonimmunological agents such as carrageenan or croton oil. We suggest that one mechanism of the antiinflammatory activity of alkaloid may be directly blocking PLA2 catalyzed release of arachidonic acid. Moreover, this study demonstrates that aristolochic acid could also inhibit other steps involved in eicosanoids release such as cyclooxygenase and lipooxygenase pathways." @default.
- W2023876067 created "2016-06-24" @default.
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- W2023876067 date "1993-07-01" @default.
- W2023876067 modified "2023-09-26" @default.
- W2023876067 title "Effect of aristolochic acid on arachidonic acid cascade and in vivo models of inflammation" @default.
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- W2023876067 doi "https://doi.org/10.1016/0162-3109(93)90061-t" @default.
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