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- W2023876962 abstract "Although hypothermia decreases cardiac output, oxygen consumption by the tissues is thought to decrease proportionately, so that tissue hypoxia does not occur. Hemodilution has been shown to increase cardiac output and tissue oxygenation. We hypothesize that hemodilution may be harmful by increasing cardiac output and oxygen need in excess of oxygen delivery. Oxygen consumption (V02) and arterial and venous blood gases were measured directly in 5 anesthetized dogs before and after cooling to 30°C and again after hemodilution (H) with Dextran 75. Cardiac index (CI), oxygen delivery (D02), oxygen extraction rate (02 ext) and oxygen equivalent (02 eq) were then calculated. Results are shown in the table below. (H=hemodilution, V02 units are cc/kg/min, *p<.05, ** p<.01). Although neither hypothermia nor hemodilution alone result in increased oxygen extraction, mild hypothermia and hemodilution together produce increased 02 extraction in order to avoid tissue hypoxia. It is possible that although hemodilution increased cardiac output, microvascular flow remained impaired necessitating increased oxygen extraction." @default.
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- W2023876962 date "1985-04-01" @default.
- W2023876962 modified "2023-10-16" @default.
- W2023876962 title "186 OXYGEN TRANSPORT IN HYPOTHERMIC DOGS WITH AND WITH OUT HEMODILUTION" @default.
- W2023876962 doi "https://doi.org/10.1203/00006450-198504000-00216" @default.
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