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- W2023878886 abstract "Cell migration and invasion leading to metastasis is a major cause of death from endometrial cancer (EC). We have shown that the rate of EC cell migration is inversely related to the level of insulin-like growth factor protein-3 (IGFBP-3). Down-regulation of IGFBP-3 by siRNA in EC cells accelerated migration without affecting proliferation and cells displayed a more migratory phenotype, with co-localization of migration-associated markers at the leading edge of cell membranes. Opposite effects were seen with either the addition of recombinant IGFBP-3 or overexpression of IGFBP-3. Cells with mutated PTEN had the highest IGFBP-3 expression and the slowest migration rates. This study demonstrates that endogenous IGFBP-3 modulates adhesion–migration dynamics in EC cells, implying that it may be important in regulating metastasis in this disease." @default.
- W2023878886 created "2016-06-24" @default.
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- W2023878886 date "2012-04-01" @default.
- W2023878886 modified "2023-09-26" @default.
- W2023878886 title "Insulin-like growth factor binding protein-3 inhibits migration of endometrial cancer cells" @default.
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- W2023878886 doi "https://doi.org/10.1016/j.canlet.2011.11.011" @default.
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