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- W2023879960 endingPage "484" @default.
- W2023879960 startingPage "477" @default.
- W2023879960 abstract "Piscirickettsia salmonis is pathogenic for a variety of cultured marine fish species worldwide. The organism has been observed within host macrophages in natural disease outbreaks among coho salmon and European sea bass. In vitro studies, incorporating transmission electron microscopy (TEM) and ferritin loading of lysosomes, have confirmed that P. salmonis is capable of surviving and replicating in rainbow trout macrophages. Certain features of this intracellular survival underline its difference to other intracellular pathogens and suggest that a novel combination of defence mechanisms may be involved. Escape into the macrophage cytoplasm is not used as a means to avoid phago-lysosomal fusion and the organism remains at least partly enclosed within a vacuole membrane. While the piscirickettsial vacuole is often incomplete, survival and replication appear to require occupation of a complete, tightly-apposed, vacuolar membrane which does not fuse with lysosomes. Unlike some mammalian rickettsiae, actin-based motility (ABM) is not used as a means of intercellular spread. It is postulated that the presence of numerous small vesicles within vacuoles, and at gaps in the vacuolar membrane, may result from the blebbing of the piscirickettsial outer membrane seen early in the infection." @default.
- W2023879960 created "2016-06-24" @default.
- W2023879960 creator A5001943879 @default.
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- W2023879960 creator A5060685524 @default.
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- W2023879960 creator A5083902012 @default.
- W2023879960 date "2008-11-01" @default.
- W2023879960 modified "2023-10-06" @default.
- W2023879960 title "Survival and replication of Piscirickettsia salmonis in rainbow trout head kidney macrophages" @default.
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