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- W2023880022 abstract "Recently, an association between childhood growth stunting and aflatoxin (AF) exposure has been identified. In Ghana, homemade nutritional supplements often consist of AF-prone commodities. In this study, children were enrolled in a clinical intervention trial to determine the safety and efficacy of Uniform Particle Size NovaSil (UPSN), a refined calcium montmorillonite known to be safe in adults. Participants ingested 0.75 or 1.5 g UPSN or 1.5 g calcium carbonate placebo per day for 14 days. Hematological and serum biochemistry parameters in the UPSN groups were not significantly different from the placebo-controlled group. Importantly, there were no adverse events attributable to UPSN treatment. A significant reduction in urinary metabolite (AFM1) was observed in the high-dose group compared with placebo. Results indicate that UPSN is safe for children at doses up to 1.5 g/day for a period of 2 weeks and can reduce exposure to AFs, resulting in increased quality and efficacy of contaminated foods." @default.
- W2023880022 created "2016-06-24" @default.
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- W2023880022 date "2014-10-01" @default.
- W2023880022 modified "2023-09-27" @default.
- W2023880022 title "Short-Term Safety and Efficacy of Calcium Montmorillonite Clay (UPSN) in Children" @default.
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- W2023880022 doi "https://doi.org/10.4269/ajtmh.14-0093" @default.
- W2023880022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4183404" @default.
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