FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023881880> ?p ?o ?g. }

• W2023881880 endingPage "191" @default.
• W2023881880 startingPage "181" @default.
• W2023881880 abstract "Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants that have been linked to certain human cancers. The fjord region PAH dibenzo[a,l]pyrene exhibits the highest levels of carcinogenic activity of all PAH as yet tested in rodent tumor models. Another hexacyclic aromatic hydrocarbon, dibenzo[c,p]chrysene (DBC), is a unique PAH that possesses one bay region and two fjord regions within the same molecule. Due to its structure, which is a merger of the fjord region PAHs benzo[c]phenanthrene, benzo[c]chrysene, and benzo[g]chrysene, DBC is of considerable research interest. In order to investigate the pathway of regioselective metabolism we have studied the cytotoxicity, metabolic activation and DNA adduct formation of DBC in human mammary carcinoma MCF-7 cells in culture. The cytotoxicity assay indicated undisturbed cell proliferation even at concentrations as high as 4.5 μM (1.5 μg/ml) DBC. Concurrently, DNA adducts were detected in MCF-7 cells treated with DBC only in low amounts (0.6 pmol adducts/mg DNA). On the contrary, exposure to anti-DBC-1,2-diol-3,4-epoxide and anti-DBC-11,12-diol-13,14-epoxide, two putatively genotoxic metabolites of DBC, resulted in high levels of DNA adducts (33 and 51 pmol adducts/mg DNA, respectively). Although DBC was not efficiently transformed into DNA-reactive metabolites in MCF-7 cells in culture, the results from our study indicate that the two fjord region diol-epoxide derivatives of DBC may serve as ultimate genotoxic metabolites once they are enzymatically generated under certain circumstances in vitro or in vivo." @default.
• W2023881880 created "2016-06-24" @default.
• W2023881880 creator A5001311093 @default.
• W2023881880 creator A5009077760 @default.
• W2023881880 creator A5026277311 @default.
• W2023881880 creator A5048058203 @default.
• W2023881880 creator A5058407421 @default.
• W2023881880 creator A5076480656 @default.
• W2023881880 creator A5079625917 @default.
• W2023881880 date "2006-12-01" @default.
• W2023881880 modified "2023-09-23" @default.
• W2023881880 title "Investigation of the genotoxicity of dibenzo[c,p]chrysene in human carcinoma MCF-7 cells in culture" @default.
• W2023881880 cites W1556247718 @default.
• W2023881880 cites W1576212556 @default.
• W2023881880 cites W1646419439 @default.
• W2023881880 cites W1915747648 @default.
• W2023881880 cites W1963863410 @default.
• W2023881880 cites W1977246633 @default.
• W2023881880 cites W1981053174 @default.
• W2023881880 cites W1989734490 @default.
• W2023881880 cites W1990934241 @default.
• W2023881880 cites W1994642683 @default.
• W2023881880 cites W1994700344 @default.
• W2023881880 cites W1994824322 @default.
• W2023881880 cites W1996033279 @default.
• W2023881880 cites W2004988801 @default.
• W2023881880 cites W2010272845 @default.
• W2023881880 cites W2011182408 @default.
• W2023881880 cites W2017418899 @default.
• W2023881880 cites W2021998165 @default.
• W2023881880 cites W2024386749 @default.
• W2023881880 cites W2027433468 @default.
• W2023881880 cites W2047878898 @default.
• W2023881880 cites W2050490901 @default.
• W2023881880 cites W2054836547 @default.
• W2023881880 cites W2073571283 @default.
• W2023881880 cites W2079542036 @default.
• W2023881880 cites W2089706668 @default.
• W2023881880 cites W2091231452 @default.
• W2023881880 cites W2091430075 @default.
• W2023881880 cites W2092789969 @default.
• W2023881880 cites W2112893029 @default.
• W2023881880 cites W2114700904 @default.
• W2023881880 cites W2115285962 @default.
• W2023881880 cites W2116452745 @default.
• W2023881880 cites W2128516757 @default.
• W2023881880 cites W2130251223 @default.
• W2023881880 cites W2140131706 @default.
• W2023881880 cites W2143582296 @default.
• W2023881880 cites W2152083368 @default.
• W2023881880 cites W2156485427 @default.
• W2023881880 cites W2187112694 @default.
• W2023881880 cites W2951137341 @default.
• W2023881880 cites W307860133 @default.
• W2023881880 doi "https://doi.org/10.1016/j.cbi.2006.09.015" @default.
• W2023881880 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1794669" @default.
• W2023881880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17094953" @default.
• W2023881880 hasPublicationYear "2006" @default.
• W2023881880 type Work @default.
• W2023881880 sameAs 2023881880 @default.
• W2023881880 citedByCount "11" @default.
• W2023881880 countsByYear W20238818802012 @default.
• W2023881880 countsByYear W20238818802013 @default.
• W2023881880 countsByYear W20238818802015 @default.
• W2023881880 countsByYear W20238818802017 @default.
• W2023881880 countsByYear W20238818802019 @default.
• W2023881880 countsByYear W20238818802021 @default.
• W2023881880 countsByYear W20238818802022 @default.
• W2023881880 crossrefType "journal-article" @default.
• W2023881880 hasAuthorship W2023881880A5001311093 @default.
• W2023881880 hasAuthorship W2023881880A5009077760 @default.
• W2023881880 hasAuthorship W2023881880A5026277311 @default.
• W2023881880 hasAuthorship W2023881880A5048058203 @default.
• W2023881880 hasAuthorship W2023881880A5058407421 @default.
• W2023881880 hasAuthorship W2023881880A5076480656 @default.
• W2023881880 hasAuthorship W2023881880A5079625917 @default.
• W2023881880 hasBestOaLocation W20238818802 @default.
• W2023881880 hasConcept C107872376 @default.
• W2023881880 hasConcept C114246631 @default.
• W2023881880 hasConcept C120665830 @default.
• W2023881880 hasConcept C121332964 @default.
• W2023881880 hasConcept C178790620 @default.
• W2023881880 hasConcept C185592680 @default.
• W2023881880 hasConcept C193523891 @default.
• W2023881880 hasConcept C2775959351 @default.
• W2023881880 hasConcept C2776891815 @default.
• W2023881880 hasConcept C2777477808 @default.
• W2023881880 hasConcept C2777538855 @default.
• W2023881880 hasConcept C2778951431 @default.
• W2023881880 hasConcept C2778959862 @default.
• W2023881880 hasConcept C2779033964 @default.
• W2023881880 hasConcept C2781247443 @default.
• W2023881880 hasConcept C29730261 @default.
• W2023881880 hasConcept C55493867 @default.
• W2023881880 hasConcept C71240020 @default.
• W2023881880 hasConcept C89631360 @default.
• W2023881880 hasConceptScore W2023881880C107872376 @default.
• W2023881880 hasConceptScore W2023881880C114246631 @default.

• next